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Authors
Affiliations
1 Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur, IN
Source
Research Journal of Engineering and Technology, Vol 4, No 4 (2013), Pagination: 284-287
Abstract
The Present Study is to analyse the targeted delivery of Ursodiol, a drug used in the treatment of Primary Sclerosing Cholangitis (PSC) using Lipid Bilayer Nano-Particles or Solid Lipid Nano Particles(SLNPs) which is taken for insilico binding studies with various 4 different liver receptors. 3 Solid Lipid Nano Particles are chosen and Binding Efficiency of the Drug with Solid Lipid Nano Particles are Studied Using DFT Analysis and FEM Analysis. It was seen that the complete drug binding is seen in Small Unilamellar Vessicle (SUV). Chosen Liver Receptors with Ursodiol of the SUV are checked for binding studies using AutoDock 4. The Study revealed that Liver X Receptor has a greater efficiency in binding with the Solid Lipid Nano Particles.
Keywords
Ursodiol, Solid Lipid Nano Particles, Small Unilamellar Vessicle, Liver Receptors.
