Open Access
Subscription Access
Open Access
Subscription Access
New Simple, Sensitive and Economical UV Spectrophotometric Method for Estimation of Risperidone in Tablet Dosage Form and its Peroxide Degradation Kinetic.
Subscribe/Renew Journal
New simple, economic, sensitive, accurate UV Spectrophotometric method has been developed for determination of Risperidone in tablet dosage form. Method of estimation for Risperidone based on two wavelengths viz. 238 nm and 276 nm, by solvent mixture of 0.1N HCl: Methanol in the proportion of 30:70. Risperidone shows linearity and obeys Beer’s law in the concentration range of 3 to 27μg ml-1 at both wavelengths. The results of analysis are validated by statistical evaluation and recovery studies, and method can be extended to the analysis of Risperidone in tablet formulations. A kinetic investigation of the peroxide hydrolysis of Risperidone was carried out in 1% and 3% Hydrogen peroxide solution. The rate constant for degradation were estimated as per pseudo-first order kinetic.
Keywords
Risperidone, UV Spectrophotometric Method, λmax, Degradation Kinetic.
Subscription
Login to verify subscription
User
Font Size
Information
Abstract Views: 258
PDF Views: 0