Research Journal of Pharmaceutical Dosage Form and Technology

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A Review on Buccal Drug Delivery System


Affiliations
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, India
     

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Bio adhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to biological surface for an extended period of time. Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. The buccal mucosa is considered to be a promising site for the systemic delivery of drugs where a rapid onset of action is required and for drugs that are not easily administered via other routes than by injection. The buccal mucosa being a highly vascularised area helps in rapid systemic absorption of the drug, thereby avoiding hepatic “first-pass effect” of drugs leading to quicker onset of action, which could be especially important in the management of crisis situations like cardiac arrest, epileptic seizures, severe nausea and vomiting. This article aims at reviewing on buccal drug delivery system which includes the mechanism and factors affecting buccal absorption and the methods to increase drug delivery via buccal route.

Keywords

Bioadhesion, Buccal Mucosa, First-Pass Effect, Cardiac Arrest, Epileptic Seizures.
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  • A Review on Buccal Drug Delivery System

Abstract Views: 271  |  PDF Views: 0

Authors

M. N. L. Aishwarya
Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, India
V. Prudhvi Raj
Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, India
Subhashis Debnath
Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, India
M. Niranjan Babu
Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, India

Abstract


Bio adhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to biological surface for an extended period of time. Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. The buccal mucosa is considered to be a promising site for the systemic delivery of drugs where a rapid onset of action is required and for drugs that are not easily administered via other routes than by injection. The buccal mucosa being a highly vascularised area helps in rapid systemic absorption of the drug, thereby avoiding hepatic “first-pass effect” of drugs leading to quicker onset of action, which could be especially important in the management of crisis situations like cardiac arrest, epileptic seizures, severe nausea and vomiting. This article aims at reviewing on buccal drug delivery system which includes the mechanism and factors affecting buccal absorption and the methods to increase drug delivery via buccal route.

Keywords


Bioadhesion, Buccal Mucosa, First-Pass Effect, Cardiac Arrest, Epileptic Seizures.

References