Research Journal of Pharmaceutical Dosage Form and Technology

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A concise review on analytical profile of chlorthalidone


Affiliations
1 Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda: 425107, Maharashtra,, India
2 Department of Pharmaceutical Chemistry, TSPM’s, Trimurti Institute of Pharmacy, Paldhi (Bk): 425103, Jalgaon, Maharashtra,, India
3 Department of Pharmaceutics, TSPM’s, Trimurti Institute of Pharmacy, Paldhi (Bk): 425103, Jalgaon, Maharashtra,, India
4 4Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur: 425405, Dhule, Maharashtra,, India
     

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Chlorthalidone (CHL) is an anti-hypertensive that reduces active sodium reabsorption and peripheral vascular resistance. Also, it is a diuretic commonly known as a thiazide diuretic. Due to the huge amount of use of CHL in different dosage forms for the management of hypertension, it needs qualitative and quantitative estimation in the pharmaceutical and biological formulation. Therefore, the main objective of this analysis of CHL in the pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis Spectroscopy, high-performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Ultra performance liquid chromatography (UPLC), etc. based methods for estimation of chlorthalidone. In addition to that, we have discussed the bioanalytical methods for CHL analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids.

Keywords

Chlorthalidone, Anti-hypertensive, Analytical methods, High-performance liquid chromatography, Bioanalytical methods.
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  • A concise review on analytical profile of chlorthalidone

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Authors

Yogesh A. Chaudhari
Department of Pharmaceutics, Smt. S. S. Patil College of Pharmacy, Chopda: 425107, Maharashtra,, India
Vikas R. Patil
Department of Pharmaceutical Chemistry, TSPM’s, Trimurti Institute of Pharmacy, Paldhi (Bk): 425103, Jalgaon, Maharashtra,, India
Rakesh R. Gujar
Department of Pharmaceutics, TSPM’s, Trimurti Institute of Pharmacy, Paldhi (Bk): 425103, Jalgaon, Maharashtra,, India
Kuldip R. Patil
Department of Pharmaceutics, TSPM’s, Trimurti Institute of Pharmacy, Paldhi (Bk): 425103, Jalgaon, Maharashtra,, India
Sopan Nangare
4Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur: 425405, Dhule, Maharashtra,, India

Abstract


Chlorthalidone (CHL) is an anti-hypertensive that reduces active sodium reabsorption and peripheral vascular resistance. Also, it is a diuretic commonly known as a thiazide diuretic. Due to the huge amount of use of CHL in different dosage forms for the management of hypertension, it needs qualitative and quantitative estimation in the pharmaceutical and biological formulation. Therefore, the main objective of this analysis of CHL in the pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis Spectroscopy, high-performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Ultra performance liquid chromatography (UPLC), etc. based methods for estimation of chlorthalidone. In addition to that, we have discussed the bioanalytical methods for CHL analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids.

Keywords


Chlorthalidone, Anti-hypertensive, Analytical methods, High-performance liquid chromatography, Bioanalytical methods.

References