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A Glance at the Literature review on Buccal films


Affiliations
1 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
     

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The present article concentrates on the Buccal film. It is a buccoadhesive drug delivery system that enhances the safety, efficacy, and stability of active pharmaceutical ingredients. The buccal film is a novel technology due to its better option to optimize therapeutic efficacy. This drug delivery system is suitable for drugs that pass through high first-pass metabolism and are used for enhancing bioavailability. The buccal film can be formulated as a solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, or rolling method. Among them, the solvent casting method is mostly adopted. The buccal films are evaluated for mechanical properties viz., Organoleptic assessment, thickness, dryness, tack test, tensile strength, percent elongation, folding endurance, swelling assets, surface pH, contact angle, transparency, uniformity in drug content, disintegration, and in-vitro dissolution tests. The article gave a handful of literature on past work done on buccal films. This article helps with quick references to the earlier attempts so far made on buccal films.

Keywords

Buccal, Bioavailability, Film, Literature, Patient convenience.
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  • Ahad HA, Chinthaginjala H, Priyanka MS, Raghav DR, Gowthami M, Jyothi VN. Datura stramonium Leaves Mucilage Aided Buccoadhesive Films of Aceclofenac using 32 Factorial Design with Design-Expert Software.
  • Kumria R, Nair AB, Goomber G, Gupta S. Buccal films of prednisolone with enhanced bioavailability. Drug delivery. 2016 Feb 12;23(2):471-8.
  • Ahad HA, Ksheerasagare T, Chelluru A, Haranath C, Reddy GS, Krishna JV. Herbal Mucilage attempted as a Super disintegrating agent in Oral Disintegrating Tablets. Research Journal of Pharmacy and Technology. 2020 Nov 1;13(11):5489-92.
  • Al-Dhubiab BE, Nair AB, Kumria R, Attimarad M, Harsha S. Development, and evaluation of buccal films impregnated with selegiline-loaded nanospheres. Drug delivery. 2016 Sep 1;23(7):2154-62.
  • Hindustan AA, Babu UA, Nagesh K, Kiran DS, Madhavi KB. Fabrication of glimepiride Datura stramonium leaves mucilage and poly vinyl pyrrolidone sustained release matrix tablets: in vitro evaluation. Kathmandu university journal of science, engineering, and technology. 2012;8(1):63-72.
  • Zayed GM, Abd-El Rasoul S, Ibrahim MA, Saddik MS, Alshora DH. In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films. Saudi pharmaceutical journal. 2020 Mar 1;28(3):266-73.
  • Khana R, Agarwal SP, Ahuja A. Preparation, and evaluation of muco-adhesive buccal films of clotrimazole for oral Candida infections. Indian Journal of pharmaceutical sciences. 1997;59(6):299.
  • Raghuraman S, Velrajan G, Ravi R, Jeyabalan B, Johnson DB, Sankar V. Design, and evaluation of propranolol hydrochloride buccal films. Indian journal of pharmaceutical sciences. 2002;64(1):32
  • Chowdary KR, Rao NK, Malathi K. Ethyl cellulose microspheres of glipizide: Characterization, in vitro and in vivo evaluation. Indian Journal of pharmaceutical sciences. 2004;66(4):412.
  • Alanazi FK, Rahman AA, Mahrous GM, Alsarra IA. Formulation and physicochemical characterisation of buccoadhesive films containing ketorolac. Journal of drug delivery science and technology. 2007 Jan 1;17(3):183-92.
  • M, Semalty A, Kumar G. Formulation, and characterization of mucoadhesive buccal films of glipizide. Indian Journal of Pharmaceutical Sciences. 2008 Jan;70(1):43.
  • Singh S, Jain S, Muthu MS, Tiwari S, Tilak R. Preparation, and evaluation of buccal bioadhesive films containing clotrimazole. Aaps Pharmscitech. 2008 Jun;9(2):660-7.
  • Nappinnai M, Chandanbala R, Balaijirajan R. Formulation, and evaluation of nitrendipine buccal films. Indian journal of pharmaceutical sciences. 2008 Sep;70(5):631.
  • Satishbabu BK, Srinivasan BP. Preparation and evaluation of buccoadhesive films of atenolol. Indian journal of pharmaceutical sciences. 2008 Mar;70(2):175.
  • Ubarhande YB, Regupathy T, Vijaya C, Deshmane SV. Formulation and evaluation of mucoadhesive buccal films of losartan potassium. Research Journal of Pharmacy and Technology. 2009;2(4):833-6.
  • Mura P, Corti G, Cirri M, Maestrelli F, Mennini N, Bragagni M. Development of mucoadhesive films for buccal administration of flufenamic acid: effect of cyclodextrin complexation. Journal of pharmaceutical sciences. 2010 Jul 1;99(7):3019-29
  • Cilurzo F, Cupone IE, Minghetti P, Buratti S, Selmin F, Gennari CG, Montanari L. Nicotine fast dissolving films made of maltodextrins: a feasibility study. Aaps Pharmscitech. 2010 Dec;11(4):1511-7.
  • Singhal P, Jadoun GS, Sinha M, Saraf SA. Formulation and evaluation of buccal patches of terbutaline sulphate. Int J Res Pharm Sci. 2010; 4:440-9.
  • El-Setouhy DA, Abd El-Malak NS. Formulation of a novel tianeptine sodium orodispersible film. Aaps Pharmscitech. 2010 Sep;11(3):1018-25
  • Mahajan A. Formulation and evaluation of fast dissolving buccal films of sertraline. Int J Drug Dev Res. 2012 Jan;4(1):220-6.
  • Panchal MS, Patel H, Bagada A, Vadalia KR. Formulation, and evaluation of mouth dissolving film of ropinirole hydrochloride by using pullulan polymers. International Journal of Pharmaceutical Research & Allied Sciences. 2012;1(3):60-72.
  • Pandey S. Formulation and evaluation of buccal patches of Diclofenac Sodium. International Journal of Scientific & Engineering Research. 2012;3(12):1-7.
  • Nautiyal U. Development and evaluation of buccal film. International Journal of Pharmaceutical and Medicinal Research. 2013 Sep 13; 1:39-43.
  • Lodhi M, Dubey A, Narayan R, Prabhu P, Priya S. Formulation, and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris. International journal of pharmaceutical investigation. 2013 Jan;3(1):47.
  • Roy AK, Vinod Kumar SM, Bashal SJ, Haque R, Kark R. Formulation, and evaluation of mucoadhesive buccal tablets of valsartan. International Journal of Drug Delivery and Research. 2013; 5:145-55.
  • Lodhi M, Dubey A, Narayan R, Prabhu P, Priya S. Formulation, and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris. International journal of pharmaceutical investigation. 2013 Jan;3(1):47.
  • Kumria R, Gupta V, Bansal S, Wadhwa J, Nair AB. Oral buccoadhesive films of ondansetron: development and evaluation. International journal of pharmaceutical investigation. 2013 Apr;3(2):112.
  • Chandra D, Chaurasia S, Singh VK, Yadav KK. Chitosan Based Mucoadhesive Microsphere: Versatile Carrier for Nasal Drug Delivery System. WJPR. 2014 Jun 20;3(6):1368-85.
  • Sai Sathavahana C, Allena RT, Getyala A, Gangadharappa H. Formulation and Evaluation of Dextromethorphan Hydrobromide Controlled Release Hollow Microspheres using Natural Polymer. Indones. J. Pharm. 2014; 25:181-8.
  • El-Maghraby GM, Abdelzaher MM. Formulation and evaluation of simvastatin buccal film. Journal of Aplied Pharmaceutical Science. 2015 Apr;5(04):70-7.
  • Haque SE, Sheela A. Development of polymer-bound fastdissolving metformin buccal film with disintegrants. International journal of nanomedicine. 2015;10(Suppl 1):199.
  • Al-Dhubiab BE, Nair AB, Kumria R, Attimarad M, Harsha S. Development, and evaluation of buccal films impregnated with selegiline-loaded nanospheres. Drug delivery. 2016 Sep 1;23(7):2154-62.
  • Verma N, Verma A, Dubey J. Formulation and Evaluation of chitosan containing mucoadhesive buccal patches of metoprolol succinate. Journal of drug delivery and therapeutics. 2016 Mar 14;6(2):14-20.
  • Yildiz Pekoz A, Sedef Erdal M, Okyar A, Ocak M, Tekeli F, Kaptan E, Sagirli O, Araman A. Preparation, and in-vivo evaluation of dimenhydrinate buccal mucoadhesive films with enhanced bioavailability. Drug development and industrial pharmacy. 2016 Jun 2;42(6):916-25.
  • Salehi S, Boddohi S. New formulation, and approach for mucoadhesive buccal film of rizatriptan benzoate. Progress in biomaterials. 2017 Dec;6(4):175-87.
  • Ali MA, Sabati AM, Ali BA. Formulation and Evaluation of Baclofen Mucoadhesive Buccal Films. FABAD Journal of Pharmaceutical Sciences. 2017 Jul 1;42(3):179-90.
  • Saha P, Das PS. Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis. Research Journal of Pharmaceutical Dosage Forms and Technology. 2017;9(4):163-7.
  • Ali MA, Sabati AM, Ali BA. Formulation and Evaluation of Baclofen Mucoadhesive Buccal Films. FABAD Journal of Pharmaceutical Sciences. 2017 Jul 1;42(3):179-90.
  • Çelik B. Risperidone mucoadhesive buccal tablets: formulation design, optimization, and evaluation. Drug design, development, and therapy. 2017; 11:3355.
  • Zaman M, Hanif M, Shaheryar ZA. Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation. PloS one. 2018 Mar 22;13(3): e0194410
  • Alam MM, Minj E, Yadav RK, Mehan S. Neuroprotective potential of adenyl cyclase/cAMP/CREB and mitochondrial CoQ10 activator in amyotrophic lateral sclerosis rats. Curr. Bioact. Compd. 2020; 16:1-8.
  • Fernandes FP, Fortes AC, da Cruz Fonseca SG, Breitkreutz J, Ferraz HG. Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide. International Journal of Polymer Science. 2018 Jan 1;2018.
  • Begum SK, Sura RS, Phanindra B, Kumar PP. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Captopril. Research Journal of Pharmaceutical Dosage Forms and Technology. 2019;11(3):164-8.
  • Basahih TS, Alamoudi AA, El-Say KM, Alhakamy NA, Ahmed OA. Improved transmucosal delivery of glimepiride via unidirectional release buccal film loaded with Vitamin E TPGSbased nanocarrier. Dose-Response. 2020 Jul 31;18(3):1559325820945164.

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  • A Glance at the Literature review on Buccal films

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Authors

Yarragunta Roja
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
Hindustan Abdul Ahad
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
Haranath Chinthaginjala
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
Maninjeri Soumya
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
Sana Muskan
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India
Nagaraju gari Kavyasree
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu, Andhra Pradesh,, India

Abstract


The present article concentrates on the Buccal film. It is a buccoadhesive drug delivery system that enhances the safety, efficacy, and stability of active pharmaceutical ingredients. The buccal film is a novel technology due to its better option to optimize therapeutic efficacy. This drug delivery system is suitable for drugs that pass through high first-pass metabolism and are used for enhancing bioavailability. The buccal film can be formulated as a solvent casting, semi-solid casting, hot-melt extrusion, solid dispersion, or rolling method. Among them, the solvent casting method is mostly adopted. The buccal films are evaluated for mechanical properties viz., Organoleptic assessment, thickness, dryness, tack test, tensile strength, percent elongation, folding endurance, swelling assets, surface pH, contact angle, transparency, uniformity in drug content, disintegration, and in-vitro dissolution tests. The article gave a handful of literature on past work done on buccal films. This article helps with quick references to the earlier attempts so far made on buccal films.

Keywords


Buccal, Bioavailability, Film, Literature, Patient convenience.

References