Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Floating Drug Delivery System: A Novel apporach for Delivery of Drug on Targated Organ


Affiliations
1 Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
2 Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
3 Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
     

   Subscribe/Renew Journal


The goal of this review on floating drug delivery systems (FDDS) was to compile latest data with a particular focus on the main mechanism of flotation for stomach retention. Drug delivery systems that float instantly when they come into contact with gastric fluids are promising approaches for increasing the bioavailability of drugs within absorption window in the stomach or upper small intestine. They are unstable in the intestinal or colonic environment and have low solubility at high pH values. The Current pharmaceutical scenario focuses on the development of sustained drug delivery systems to achieve required therapeutic concentration with less amount of dose. Oral delivery of the drug is the preferable drug delivery system. Because of the ease of administration, patient compliance and formulation flexibility. The ability to delay and control the emptying period of a dosage form in the stomach is an extremely variable process. For dosage forms that stay in the stomach for longer periods of time than standard dosage forms so the gastric transit time is a valuable asset for this system. The goal of this review article is to provide detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and applications of floating systems. These systems can help with a variety of issues that arise during the development of a pharmaceutical dosage form, as well as the potential of FDDS in the future. This review article makes an attempt to introduce readers to current developments in floating drug delivery systems.

Keywords

Floating drug delivery, GIT, Sustain release, Gastric residence time, Applications.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Shukla v et al. floating drug delivery system: an updated review Journal of Medical Pharmaceutical and Allied Sciences; (2013) 04; 31-42.

  • Raut ss et al. in-situ raft forming system: a review. international journal of pharmacognosy [internet]. 2018;5(6):337–49. available from: http://dx.doi.org/10.13040/ijpsr.0975-8232.ijp.5

  • Amit Kumar Nayak et al. gastrorententive drug delivery technologies: current approaches and future potential [internet]. (2010). available from: https://www.researchgate.net/publication/208506426

  • Rajesh Mujoriya et al. A Overview on Study of Floating Drug Delivery Systems. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1): 01-13.

  • Ch. Naga Laxmi et al, M. Ganga Bhavani, V. Floating Drug Delivery Approaches for Prolonged Gastric Retention. Research J. Pharm. and Tech 6(7): July 2013; Page 706-710.

  • S Vijaya Kumar et al, Manoj Kumar Deka. A Systematic Review on Floating Drug Delivery System. Research J. Pharm. and Tech.4 (1): January (2011); Page 19-25.

  • Nirav Patel Nagesh C et al, Chandrasekhar S. Floating drug delivery system: An innovative acceptable approach in gastroretentive drug delivery. Research J. Pharma. Dosage Forms and Tech. (2012); 4(2): 93-103.

  • Javaid mu et al comprehensive discussion about gastro retentive drug delivery system [internet]. vol. 8. (2016). available from: www.ijppr.humanjournals.com

  • Sonawane Pradnya L et al, Darekar A. B, Bilayer Floating Technology: An Innovative Approach. Asian J. Res. Pharm. Sci. 6(1): Jan.-Mar., (2016); Page 37-44.

  • K. Gnanaprakash, K.B et al. A Review on Floating Drug Delivery System of H2 Receptors. Research J. Pharm. and Tech. 4(4): April (2011); Page 502- 509.

  • Mohan kumar et al, saravanakumar k .a review on floating drug delivery systems. international journal of research in pharmaceutical sciences. (2014) sep 30;5(3):193–9.

  • Ish Grover, et al,. Floating Drug Delivery Systems: A Novel Approach. Research J. Pharm. and Tech. 8(4): April,(2015); Page 490-495.

  • Nirav Patel, Nagesh C et al. Floating drug delivery system: An innovative acceptable approach in Gastro retentive drug delivery. Asian J. Pharm. Res. 2(1): Jan.-Mar. (2012); Page 07-18.

  • A.V.S. Hima Bindu et al . Floating Drug Delivery System: An Overview. Asian Journal of Research in Pharmaceutical Sciences. (2021); 11(4):295-0.

  • Chandel a et al, chauhan k, s. floating drug delivery systems: a better approach. vol., international current pharmaceutical journal.(2012). available from: http://www.icpjonline.com/documents/vol1issue5/04.pdf


Abstract Views: 496

PDF Views: 0




  • Floating Drug Delivery System: A Novel apporach for Delivery of Drug on Targated Organ

Abstract Views: 496  |  PDF Views: 0

Authors

Pankaj. P. Sathe
Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
Kedar Bavaskar
Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India
Ashish Jain
Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., India

Abstract


The goal of this review on floating drug delivery systems (FDDS) was to compile latest data with a particular focus on the main mechanism of flotation for stomach retention. Drug delivery systems that float instantly when they come into contact with gastric fluids are promising approaches for increasing the bioavailability of drugs within absorption window in the stomach or upper small intestine. They are unstable in the intestinal or colonic environment and have low solubility at high pH values. The Current pharmaceutical scenario focuses on the development of sustained drug delivery systems to achieve required therapeutic concentration with less amount of dose. Oral delivery of the drug is the preferable drug delivery system. Because of the ease of administration, patient compliance and formulation flexibility. The ability to delay and control the emptying period of a dosage form in the stomach is an extremely variable process. For dosage forms that stay in the stomach for longer periods of time than standard dosage forms so the gastric transit time is a valuable asset for this system. The goal of this review article is to provide detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and applications of floating systems. These systems can help with a variety of issues that arise during the development of a pharmaceutical dosage form, as well as the potential of FDDS in the future. This review article makes an attempt to introduce readers to current developments in floating drug delivery systems.

Keywords


Floating drug delivery, GIT, Sustain release, Gastric residence time, Applications.

References