Research Journal of Pharmaceutical Dosage Form and Technology

Manmohan S. Jangdey ¹, Anshita Gupta ¹, Abhishek K. Sah ¹, Sanjay J. Daharwal ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN

Abstract

Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. We have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail. The purpose of this paper is to review the recent literature and current technology such as Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamic ally balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. Used in the development of gastro retentive dosage forms.

Keywords

Site-Specific Drug Delivery System, Gastric Retention, Current Technology, Gastro Retentive Dosage Forms.

Full Text

     

Manmohan S. Jangdey ¹, Anshita Gupta ¹, Abhishek K. Sah ¹, Sanjay J. Daharwal ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN

Abstract

Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. We have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail. The purpose of this paper is to review the recent literature and current technology such as Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamic ally balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. Used in the development of gastro retentive dosage forms.

Keywords

Site-Specific Drug Delivery System, Gastric Retention, Current Technology, Gastro Retentive Dosage Forms.

Full Text