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Sharma, Anil
- Formulation and Evaluation of Transdermal Patches of Nebivolol Hydrochloride
Authors
1 Gyan Vihar School of Pharmacy, SGVU, Mahal Road, Jagatpura, Jaipur, IN
2 Lordshiva College of Pharmacy, Sirsa, Haryana, IN
3 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 272-277Abstract
Aim:- The present study is to formulate the matrix type transdermal patches of Nebivolol hydrochloride as a model drug with combination of HPMC K100M and ERS-100 to minimize the dose of the drug for lesser side effect.
Method:-Matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide was used as penetration enhancer. Major
Results:-The physicochemical parameters like weight variation, thickness, folding endurance, drug content, Percentage moisture absorption and Percentage moisture loss were evaluated. All prepared formulations indicated good physical stability and no skin irritation. In-vitro drug release and drug permeation studies of formulations were performed by using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations.
Conclusions:- On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.
Keywords
Nebivolol Hydrochloride, Transdermal Patch, Polymers, Solvent Evaporation Technique, Skin Permeation.- Recent Advancements in Periodontal Drug Delivery Systems
Authors
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
3 Gyan Vihar University, Jaipur, Rajasthan, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 125-132Abstract
Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have revolutionised the therapeutic strategies for the management of periodontal disease progression. The rationale for use of antibiotics in periodontal therapy is based on the concept that bacteria are the primary cause of periodontal diseases and thus treatment should be directed towards controlling the bacterial flora.. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver antibacterials to the site of infection (periodontal pocket) has recently gained interest. This review summarises the recent developments in the field of intra-pocket drug delivery systems and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.- Chronopharmaceutics:A Clinically Relevant Approach to Drug Delivery
Authors
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
3 Suresh Gyan Vihar University, Jaipur, Rajasthan, IN