Research Journal of Pharmaceutical Dosage Form and Technology

Snehal Arjun Kurhe ¹, Kedar Bavaskar ², Ashish Jain ³

Affiliations
1 Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN
2 Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN
3 Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN

Abstract

The barrier function of the skin limits transdermal medication delivery. Vesicular systems are one of the most contentious mechanisms for delivering active compounds transdermally. The discovery of elastic vesicles such transferosomes, ethosomes, cubosomes, phytosomes, and others reignited interest in creating transdermal delivery systems. Vesicular drug delivery systems are highly organised assemblies made up of one or more concentric bilayers that form when amphiphilic building units self-assemble in water. Because of their potential to localise drug activity at the site or organ of action while reducing its concentration at other places in the body, vesicular drug delivery systems are particularly significant for targeted drug delivery. The vesicular drug delivery system keeps drug activity at a specified rate, keeps drug levels in the body reasonably constant (zero order kinetics), and reduces unwanted side effects at the same time. It can also target medication delivery utilizing carriers or chemical derivatization to localise drug action in the affected tissue or organ. Vesicular drug delivery systems have been used to improve The therapeutic index, solubility, stability, and rapid degradation of a pharmacological molecule are all important factors to consider. As a result, a number of innovative vesicular drug delivery systems that allow drug targeting and prolonged or regulated drug release have been produced. This review will focus on diverse lipoidal and non-lipoidal vesicles, with a special emphasis on pharmaceutical targeting.

Keywords

Transdermal Drug Delivery, Vesicular Delivery, Transferosome, Method of preparation, Applications.

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Supriya Vinod Pote ¹, Kedar Bavaskar ², Ashish Jain ³

Affiliations
1 Student, Department of Pharmaceutics, Shri. D. D. Vispute College of Pharmacy and Research Center, Panvel., IN
2 Assistant Professor, Department of Pharmaceutics, Shri. D. D. Vispute College of Pharmacy and Research Centre, Panvel., IN
3 3Principal, Department of Pharmacy, Shri. D. D. Vispute College of Pharmacy and Research Center, Panvel., IN

Abstract

Solubility is the process of a solid dissolving in a liquid phase, resulting in a homogeneous system. Solubility is a crucial characteristic for achieving the appropriate drug concentration in the systemic circulation and demonstrating pharmacological response. Drugs that are poorly water soluble require substantial dosages to achieve therapeutic plasma concentrations following oral administration. Low aqueous solubility is a major issue in the development of novel chemical entities' formulations. Any medicine that needs to be absorbed must be in the form of an aqueous solution at the absorption site. For liquid medicinal compositions, water is the preferred solvent. The majority of medications are weakly acidic and basic, with low water solubility. Micronization, chemical modification, pH adjustment, solid dispersion, complexation, cosolvency, micellar solubilization, hydrotropy, and other procedures are used to increase the solubility of weakly water-soluble pharmaceuticals. The goal of this review paper is to present solubilization approaches for achieving optimal absorption and increased bioavailability.

Keywords

Solubility, solubility enhancement, co-solvent, pH, emulsions.

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Pankaj. P. Sathe ¹, Kedar Bavaskar ², Ashish Jain ³

Affiliations
1 Student, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN
2 Assistant Professor, Department of Pharmaceutics, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN
3 Principal, Department of Pharmacy, Shri. D.D. Vispute College of Pharmacy and Research Center, Panvel., IN

Abstract

The goal of this review on floating drug delivery systems (FDDS) was to compile latest data with a particular focus on the main mechanism of flotation for stomach retention. Drug delivery systems that float instantly when they come into contact with gastric fluids are promising approaches for increasing the bioavailability of drugs within absorption window in the stomach or upper small intestine. They are unstable in the intestinal or colonic environment and have low solubility at high pH values. The Current pharmaceutical scenario focuses on the development of sustained drug delivery systems to achieve required therapeutic concentration with less amount of dose. Oral delivery of the drug is the preferable drug delivery system. Because of the ease of administration, patient compliance and formulation flexibility. The ability to delay and control the emptying period of a dosage form in the stomach is an extremely variable process. For dosage forms that stay in the stomach for longer periods of time than standard dosage forms so the gastric transit time is a valuable asset for this system. The goal of this review article is to provide detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and applications of floating systems. These systems can help with a variety of issues that arise during the development of a pharmaceutical dosage form, as well as the potential of FDDS in the future. This review article makes an attempt to introduce readers to current developments in floating drug delivery systems.

Keywords

Floating drug delivery, GIT, Sustain release, Gastric residence time, Applications.

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