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Barik, B. B.
- Quantization of Aceclofenac in Pharmaceutical Formulations by RP-HPLC
Authors
1 University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa.-751004, IN
2 University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa.-751004, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 52-55Abstract
An isocratic reversed phase high-performance liquid chromatographic (HPLC) method with ultraviolet detection at 281 nm has been developed for the determination of aceclofenac in dosage formulation. Good chromatographic separation aceclofenac was achieved by using a stainless steel analytical column Inertsil ODS, C18, 250 x 4.6 mm, 5 μ. The system was operated at (30±2°C) using a mobile phase consisting of buffer: acetonitrile (600:400) at a flow rate of 1.5 ml/min. The calibration curve for aceclofenac was linear over the tested concentration range of 50%, 75%, 100%, 125% and 150% with reference to the label claim and a correlation coefficient of 1.00. The intra- and inter-run precision and accuracy results were 99.07 to 100.20 with the %RSD of 0.45% and tailings factor 1.16. The proposed method was validated for its selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of aceclofenac in bulk drug as well as in formulation.
Keywords
Aceclofenac, UV Detection, RP-HPLC, Dosage Formulation, Method Validation.
- Effect of Dispersing Agent on the Characteristics of Eudragit Microspheres
Authors
1 University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751004, IN
2 University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar – 751004, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 67-71Abstract
Eudragit RS microspheres containing Indina vir sulphate for oral use were prepared using two different dispersing agents: aluminium stearate and magnesium stearate, by solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentration on the size of microspheres was studied. The morphology of microspheres was characterized by scanning electron microscopy. The surface of microspheres prepared with aluminium stearate was smoother and non-porous. When magnesium stearate was used as dispersing agents, the particle size of microspheres decreased. Increasing amounts of this dispersing agent led to the accumulation of their free particles onto the surfaces of the microspheres. The drug release from the microspheres was faster with the microspheres from aluminium stearate based on their hydrophobic structures. The encapsulation efficiency is more in case of aluminium stearate in comparison to magnesium stearate. Formulation containing aluminium stearate shows a more sustained effect than formulation containing magnesium stearate. This may due to fact that aluminium stearate is more hydrophobic in comparison to magnesium stearate.