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Alisa, C. O.
- Synthesis, Characterization and Molecular Mechanics Potential Energy Evaluation of 4-Amino-2, 3-Dimethyl-1-Phenyl-3-Pyrazolin-5-One Ligand and its Transition Metal Complexes
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Authors
Affiliations
1 Department of Chemistry, Michael Okpara University of Agriculture, Umudike, NG
2 Department of Chemistry, Federal University of Technology, Owerri, NG
1 Department of Chemistry, Michael Okpara University of Agriculture, Umudike, NG
2 Department of Chemistry, Federal University of Technology, Owerri, NG
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 2 (2015), Pagination: 129-133Abstract
4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one is a metabolite of aminopyrine with analgesic, antiinflammatory, and antipyretic properties. Cd(II), Co(II), Cu(I), Ni(II), Pt(II) and Zn(II) complexes of 4-amino- 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one have been synthesized. The ligand and complexes were characterized based on electronic, infrared, 1H NMR and 13C NMR spectroscopy. Spectroscopic investigation revealed that the ligand coordinated to the metal ions through the carbonyl and amino functional groups. 4-amino-2,3-dimethyl-1- phenyl-3-pyrazolin-5-one behaved as a bidentate ligand. Five membered ring chelates complexes were formed. Molecular mechanics potential energy evaluation showed that the most feasible position for 4-amino-2,3- dimethyl-1-phenyl-3-pyrazolin-5-one and its complexes to exhibit analgesic, anti-inflammatory and antipyretic activity was found to be in the range 56.75143626 - 82.65547188 kcal/mol.Keywords
4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Complexes, Energy, Spectra, Ligand.- Electronic and Fourier Transform Infrared Spectroscopic Characterization of Dicomponent Antimalarial Drugs Sold in Nigeria Drug Stores
Abstract Views :182 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Michael Okpara University of Agriculture, Umudike, NG
2 Department of Industrial Chemistry, Federal University of Technology, Owerri, NG
1 Department of Chemistry, Michael Okpara University of Agriculture, Umudike, NG
2 Department of Industrial Chemistry, Federal University of Technology, Owerri, NG