Research Journal of Pharmaceutical Dosage Form and Technology

A. L. Akilandeshwari ¹, K. Elango ¹, S. Daisy Chellakumari ¹, S. Kishore Kumar ¹

Affiliations
1 Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-03, IN

Abstract

The aim of the present investigation is to develop a Ramipril pulsatile drug delivery system. Pulsincap is based on an insoluble capsule body filled with Ramipril Egg albumin microspheres and cap filled with uncoated granules, separated by HPMC K4M plug. Ramipril microspheres were prepared by emulsion polymerization method with egg Albumin by varying drug to polymer ratio (1:1, 1:2, 1:3and 1:4). Granules were prepared by wet granulation method by varying concentration of superdisintegrant. Optimized microspheres were evaluated for the interaction study by FT-IR, percentage yield, angle of repose, drug content, SEM and particle size analysis. Optimized granules were evaluated for various parameters like angle of repose, carr's index and drug content. The formaldehyde treated capsule bodies were tested for physical appearance, visual defects, solubility studies and qualitative chemical test for free formaldehyde. The optimized Ramipril loaded pulsincap were evaluated for in vitro drug release and kinetic study. The drug release from optimized Ramipril pulsincap followed Zero order kinetics and mechanism of drug release was governed by peppas - korsmeyer model. Ramipril microspheres with small particle size, good loading capacity are produced by M4 formulation. G4 showed better release profile. Thus optimized formulation were formulated as pulsincap and showed in vitro release up to 24 hours.

Keywords

Pulsatile Drug Delivery, Formaldehyde Treated Capsules, Microspheres, Egg Albumin.

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I. Nishanth ¹, K. Elango ¹, N. Deattu ¹, P. Stephen ¹

Affiliations
1 Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-600003, Tamil Nadu, IN

Abstract

The aim of the study was to design bilayer tablets containing Telmisartan for immediate release and Metformin hydrochloride for sustained release. Telmisartan has the strongest binding affinity to AT1 receptor among various ARBs and also has positive effects on insulin resistance syndrome because of the partial agonistic activity towards peroxisome proliferator-activated receptor-gamma (PPARγ). Metformin is an antihyperglycemic not a hypoglycemic. Combinations of both drugs effect the treatment of hypertension in Type-II diabetes mellitus patients and improve the patient compliance. Telmisartan belongs to class II drug in BCS classification. Enhancement of solubility of Telmisartan was observed with physical mixture of drug with beta (β)-Cyclodextrin. Immediate release layers were prepared by wet granulation method using various concentration of sodium starch glycolate as superdisintegrant. SR layers were prepared by wet granulation method using swellable polymer HPMC K4 M and HPMC K100 M in different ratios. Both Immediate (L1, L2 and L3) and Sustained release (F1, F2, F3, F4 and F5) tablets were formulated and evaluated. All the values were found to be satisfactory and were within limits. From the results obtained I3 and S5 were selected and finally compressed into bilayer tablets. In vitro release studies were carried out using USP type II paddle apparatus in 0.1M HCl for first 2 hours and pH 6.8 phosphate buffer solution for next 8 hours as dissolution medium. Stability studies were carried out at 40 ± 2°c and 75±5% RH for a period of three months.

Keywords

Telmisartan, Metformin Hydrochloride, Bilayer Tablet, Wet Granulation.

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S. Ram Prasad ¹, K. Elango ¹, S. Daisy Chellakumari ¹, S. Dharani ¹

Affiliations
1 Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-03, IN

Abstract

The present study deals with preparation of silver nanoparticles using green approach such as polysaccharides method. (Chitosan was used as reducing and stabilizing agent). The prepared silver nanoparticles were characterized by UV Visible Spectroscopy, Fourier Transform Infra- red spectroscopy, Photon Correlation Spectroscopy, Scanning Electron Microscope and ICPOES. UV- Visible spectrum shows the SPR band at 420nm which confirms the formation of silver nanoparticles. The average particle size of chitosan stabilized silver nanoparticles was found to be 127.3nm. The amount of silver present in the solution was found to be 1.259mg/L using ICPOES. Chitosan stabilized silver nanoparticles were studied for anti-inflammatory activity. In vitro toxicity studies were carried out in 3T3/NIH fibroblast cell line. Using the natural environmental benign polymer chitosan, the silver nanoparticles were prepared and characterized.

Keywords

Chitosan, Silver Nanoparticles, SPR Band, SEM, ICPOES, Membrane Stabilizing Activity.

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