Research Journal of Pharmaceutical Dosage Form and Technology

K. Madhu Babu ¹, S. Kathirvel ²

Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh – 522002, IN
2 Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh - 522002, IN

Abstract

A simple, sensitive, accurate spectrophotometric method has been developed for the estimation of Tapentadol hydrochloride in bulk and pharmaceutical formulation. The method is based on the formation of blue colored chromogen with Folin-Ciocalteu reagent in the presence of NaOH and obeys beer's law in the range of 5 - 35μg/mL exhibiting the maximum absorbance at 763nm. The limit of detection and quantification were found to be 0.76#956;g/mL and 2.33#956;g/mL respectively. The calibration curve demonstrated a linear relationship between the absorbance and concentration, with the correlation coefficient higher than 0.9999. The Regression Equation of the curve was Y=0.0248x-0.0436. The method was fully validated according to ICH guidelines.

Keywords

Tapentadol Hydrochloride, Folin-Ciocalteu (FC) Reagent, NaOH, Validation, ICH Guidelines.

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A. Pavan Kumar ¹, V. Sai Kishore ², T. E. Gopala Krishna Murthy ², K. Madhu Babu ²

Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, IN
2 Bapatla College of Pharmacy, Bapatla-522101, IN

Abstract

The present investigation deals with formulation of valsartan fast dissolving tablets using co processed superdisintegrant. Crospovidone and SSG were used for preparation of co processed superdisintegrant by physical mixing and solvent evaporation method in three different ratios (1:1, 1:2, and 1:3). Six formulations are formulated with co processed superdisintegrant and are evaluated for weight variation, hardness, wetting time, water absorption ratio, disintegration time and dissolution studies and all formulations complies with pharmacoepial standards. Formulation made with co processed crospovidone and SSG in 1:1 ratio was found to be best out of all formulations. Present investigation concludes dissolution rate of valsartan fast dissolving tablets were influenced by ratios of individual superdisintegrants employed for co processed superdisintegrant and method used for preparation of co processed superdisintegrant (physical mixing vs solvent evaporation).

Keywords

Valsartan, Crospovidone, Sodium Starch Glycolate, Co-Processing.

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