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Authors
Affiliations
1 Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 1 (2017), Pagination: 15-18
Abstract
The Quality control (QC) tests like weight variation, hardness, friability, drug content, and Invitro dissolution studies were performed for three commercially available brands containing the combination of two anti diabetic drug pioglitazone (15mg) and metformin (500mg) hydrochloride. The dissolution studies were performed in 0.1N hydrochloric acid (pioglitazone HCl) up to 45 minutes and in 6.8 phosphate buffer (metformin HCl) up to 10 hours. The selected formulations satisfied QC requirements. A significant difference in dissolution parameters were noticed from the above brands. The drug dissolution from pioglitazone and metformin hydrochloride marked brand followed first order kinetics and zero order kinetics respectively.
Keywords
Pioglitazone Metformin Combination Comparative Invitro Dissolution Studies.
