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Patle, Lokesh
- An Emerging Trade in Floating Drug Delivery System - A Review
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Authors
Lokesh Patle
1,
Gopal Rai
2
Affiliations
1 Department of Pharmaceutics, Guru Ramdas Khalsa Institute of Sciences & Technology, Jabalpur (M.P.), IN
2 Guru Ramdas Khalsa Institute of Sciences & Technology, Jabalpur (M.P.), IN
1 Department of Pharmaceutics, Guru Ramdas Khalsa Institute of Sciences & Technology, Jabalpur (M.P.), IN
2 Guru Ramdas Khalsa Institute of Sciences & Technology, Jabalpur (M.P.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 6 (2013), Pagination: 371-377Abstract
The purpose this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve the physiological and formulation variables affecting gastric retention, approaches to design Effervescent and Non effervescent floating systems, and their classification and formulation aspects. It is known that differences in gastric physiology (such as, gastric pH, motility) exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior The floating or hydrodynamically controlled drug delivery systems are useful in such application. From the formulation and technological point of view, the floating drug delivery system is comparatively easy and logical approaches are discussed.Keywords
Floating Drug Delivery System, Effervescent, Noneffervescent, Evaluation, Gastric Physiology.
- Formulation and Evaluation of Ondansetron Floating Tablet
Abstract Views :207 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Sardar Patel College of Technology (B. Pharmacy), Balaghat, M.P., IN
1 Department of Pharmaceutics, Sardar Patel College of Technology (B. Pharmacy), Balaghat, M.P., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 173-179Abstract
Some drugs are absorbed in a particular portion of the GIT only or are absorbed to a different extent in various segments of the GIT. Such drugs are said to have an absorption window, which identifies the drug’s primary region of absorption in the GIT. Gastroretentive tablets of Ondansetron hcl were successfully prepared by effervescent technique using different gel forming polymers- HPMC (K15M, K4M, 15cps, 3cps), and carbopol 934. Formulation was optimized on basis of floating time and in vitro release. The prepared gastroretentive test formulation was found to exhibit satisfactory physico-chemical characteristics at the end of 30 days, during the stability studies. The optimized formulation was found to be stable at 400C/ 75% RH.Keywords
Absorption Window, Effervescent Technique, HPMC, Carbopol 934, Floating Time, Stability Studies.References
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