Research Journal of Pharmaceutical Dosage Form and Technology

P. B. Suruse ¹, M. K. Kale ², N. J. Duragkar ², A. Gundawar ²

Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongari, Hingana Road, Nagpur- 441110 (M. S.), IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 (MS), IN

Abstract

The work presented here deals with formulation and evaluation of herbal antidiabetic capsule containing dried extracts of Gymnema sylvestre, Mucuna prurience and Ginkgo biloba. Phytochemical screenings of all three extracts were performed and their purity was checked by TLC, HPTLC and also by gravimetric method. While formulating the capsules three batches were selected with different concentration of extracts of Gymnema sylvestre and same quantity of Mucuna prurience and Ginkgo biloba extracts. The antidiabetic activity of three formulations was performed on diabetic rats to find out the better activity than others. The formulation 3 has given the better result as compared to formulation 1 and 2. For the pharmacological evaluation, all the experiments were designed and conducted as per CPCSEA and IAEC guidelines. The single dose study of optimized formulation shows a significant decrease in serum glucose level at 2, 4, 6 and 24 h while comparing with only extract of Gymnema sylvestre and standard antidiabetic drug Glibenclamide. The optimized formulation showed much better result as compared to extract of Gymnema sylvestre. Physical and chemical evaluation of optimized formulation has been performed and compared the peaks of standard drug with extracts and formulation by HPTLC analysis.

Keywords

Herbal Capsule, Antidiabetic Activity, Gymnema sylvestre, Mucuna prurience, Ginkgo biloba.

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S. M. Sarode ¹, M. A. Chaudhari ², M. K. Kale ², G. Vidyasagar ²

Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN

Abstract

A mixture of oil and surfactant (especially non-ionic) forms clear and transparent isotropic solution known as self-emulsifying system (SES). Lovastatin is HMG-CoA enzyme inhibitor. This enzyme is needed by the body to make cholesterol. Lovastatin causes cholesterol to be lost from LDL, but also reduces the concentration of circulating LDL (low density lipoprotein) particles. Animals studies demonstrated that lovastatin crosses the blood-brain and placental barriers. Elderly patients or those with renal insufficiency may have higher plasma concentrations of lovastatin after administration and may require a lower dose. SEDDS is prepared and filled in hard gelatin capsules. In vitro dissolution indicates that the release of lovastatin from SEDDS varied according to the type and ratio of the oil and surfactants. It was concluded that there was an increase in both the solubility and dissolution rate of drug in SEDDS form as compared to marketed tablet.

Keywords

SEDDS, Enzymes.

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S. M. Sarode ¹, M. K. Kale ², G. S. Talele ³, G. Vidyasagar ⁴

Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN

Abstract

The phenomenon of absorption via a limited part of the GI tract has been termed the "narrow absorption window", once the dosage form passes the absorption window, the drug will be neither bioavailable nor effective. In extreme cases, drugs, e.g. methyldopa, Captopril, that are insufficiently absorbed due to narrow absorption cannot be delivered entirely, and are either given by a parentral route, or the development of such medication, which is otherwise safe and effective, is stopped altogether. Diltiazem HCL is a calcium channel blocker widely used for the treatment of angina pectoris, arrhythmias and hypertension. Its short biological half life and thus frequent administration (usually three to four times a day) makes it a potential candidate for CR: SR preparations. It has a short plasma half life of about 3 hours. Diltiazem HCL microspheres were prepared by chemical cross linking method. The microspheres were spherical, discrete and free-flowing. Encapsulation efficiency was found to be 95.62 %. Diltiazem HCL release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres.

Keywords

Microencapsulation, Controlled Release, Chitosan.

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S. M. Sarode ¹, G. Vidya Sagar ², M. K. Kale ³, P. K. Nimase ⁴, A. P. Kulkarni ³, S. D. Firke ³, B. M. Firke ³, P. D. Warke ³, M. A. Chaudhari ³

Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN

Abstract

The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.

Keywords

Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.

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S. M. Sarode ¹, M. K. Kale ², G. Vidyasagar ³

Affiliations
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN

Abstract

The pain is symptomatic of some form of dysfunction and resultant inflammatory processes in the body. More than 15% of the worldwide population suffers for instance from some form of osteoarthritis and this incidence is even higher in elderly. As the world population is grows older, this incidence will continue to rise. Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities and due to its preferential cox-2 blockade it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system. Ethyl cellulose microspheres of Aceclofenac were prepared by emulsion- solvent evaporation technique that is an industrially feasible technique. The microspheres are spherical, discrete and free-flowing. Encapsulation efficiency was found to be 81%. Aceclofenac release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres. These microspheres were found suitable for oral controlled release.

Keywords

Microencapsulation, Controlled Release, Aceclofenac.

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D. S. Saindane ¹, A. S. Kulkarn ², A. N. Sagri ², R. B. Pimprikar ³, S. B. Yeshwante ³, C. P. Suryawanshi ³, S. D. Firke ⁴, M. K. Kale ⁴

Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN

Abstract

This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.

Keywords

Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.

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M. D. Patil ¹, R. V. Keny ², R. B. Pimprikar ³, S. B. Yashwante ³, D. S. Saindane ³, S. K. Mandlik ², Mujawar Tabrej ³, M. K. Kale ⁴, B. M. Firke ⁴

Affiliations
1 255- Shramsafalya, Niwas, Janta Park, Navapur, Dist. Nandurbar, MS, PIN- 425418, IN
2 Government College of Pharmacy, Goa, IN
3 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S.), IN

Abstract

The effect of molecular weight of polyethylene glycols (PEGS) and drug/PEG ratio on the structure and dissolution rates of the solid dispersions with Telmisartan have been examined. Telmisartan (TEL) was chosen as a model drug due to its poor and pH dependent water solubility. The alkalizer used to modify the pH of TEL was NaOH, in the SD system significantly increased the drug dissolution rate in gastric fluid (pH 1.2) . Structural change in drug crystallinity to an amorphous form was also a contributing factor based on differential scanning calorimetry (DSC) thermograms and powder X-ray diffraction (PXRD) patterns. The drug frequency of the C=O band decreased and the O–H broad band in the Fourier transform infrared (FTIR) spectra disappeared when this alkalizer was added. It was evident that the alkalizer in PEG 6000 based SDs synergistically enhanced dissolution of TEL not only by modulating pH but also by changing drug crystallinity to an amorphous form via molecular interactions.

Keywords

Telmisartan (TEL), Solid Dispersion (SD), Alkalizer, Hot Melt Method.

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