Research Journal of Pharmaceutical Dosage Form and Technology

N. K. Hada ¹, M. S. Ashawat ¹

Affiliations
1 Laureate Institute of Pharmacy, Kathog, Hamirpur, Himachal Pradesh, IN

Abstract

Recent advancement within the space of biotechnology and genetics science has resulted in promotion of proteins and peptides as a major class of therapeutic agents. Administration of the bioactive molecules in their active state has been an enormous task to the pharmaceutical additionally as biotechnological industries. Drug associated challenges like appropriate route of drug delivery, physical and chemical instability, poor bioavailability, and potentially serious side effects of these bioengineered molecules are some potential limitations on their successful formulation. While developing these formulations, the goal is to obtain delivery system with optimized drug loading and release properties, long shelf-life and low toxicity. Several types of NDDS have been developed for last few decades which are aquasome, liposomes, niosomes, pharmacosomes, microparticles, nanoparticles, dendrimers, multiple emulsions, microemulsions, osmotic-modulated drug delivery system, transdermal-therapeutic system, self-regulated and braintargated drug delivery system etc. consider as promising carrier for the delivery of a broad range of molecules includes xenobiotics, viral antigens, haemoglobin and insulin. Whereever medicine area allowed to absorb on the surface of nanoparticales within the presence of carbohydrates film that prevent soft drugs from changing shaped and being damaged when surface bound.

Keywords

Water Bodies, Self-Assembling Carrier System, Nano Particulate , Nanocrystalline Core, Supramolecule, Bio-Actives Etc.

Full Text

     

M. S. Ashawat ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai, CG, IN

Abstract

Extensive efforts have been made to the administration of drugs, via alternative routes, that are poorly absorbed after the oral administration. The vaginal route of drug delivery has been known since ancient times for gynecological disorder. Traditional drug delivery systems for vaginal and oral application have employed waxes, oils, natural macromolecules, and a relatively small number of water-soluble and -insoluble synthetic polymers as critical formulation material. In recent years, the vaginal route has been experience again as a potential route for systemic delivery of special hormones and some anti-HIV and other therapeutically important macromolecules emerging with many smart and modified carrier systems are tried for gynecological disorder like Amenorrhea. However, successful delivery of drugs through the vagina remains a challenge, primarily due to the poor absorption across the vaginal epithelium. The rate and extent of drug absorption after intra vaginal administration may vary depending on formulation factors, vaginal physiology, age of the patient and menstrual cycle. The purpose of this review is to provide the reader with an awareness, diagnosis and possible treatment of Amenorrhea with summary of advances made in the field of vaginal drug delivery and provide an easy understanding of various vaginal drug delivery systems currently available in the market.

Keywords

Intra-Vaginal, Amenorrhea, Hydrogel, Bioadhesive, Dendrimer Drug Delivery.

Full Text

     

Neha Sharma ¹, Tarun Kumar Sharma ¹, Archana Chaudhary ¹, Vinay Pandit ¹, M. S. Ashawat ¹

Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Kangra (H.P.) 177101,, IN

Abstract

Fast dissolving or Quick-dissolving dosage forms have great importance in the pharmaceutical field due to their special properties and advantages. Fast-dissolving dosage forms breakdown immediately in the salivary fluids of the oral cavity within a minute, where they release the active pharmaceutical ingredient. Sublingual drug delivery system is a novel route of drug administration in which the drug substance is placed under the tongue and is directly absorbed via the blood vessels and produces the immediate onset of action. Noisome are closed bilayer vesicles formed by self-assembly of nonionic surfactant in an aqueous medium. Noisome is similar to liposome but has the ability to increase the stability of the drug. Formulated niosomes are added into the film forming polymers to obtain sublingual niosomal films. Fast dissolving niosomal film is suitable for the drugs which show high first-pass metabolism or hepatic metabolism, low bioavailability drugs, and have a short half life drugs. Fast Dissolving Niosomal Films used to improve the oral bioavailability and reduce the dose and dosing frequency, which reduce systemic side effects and as well as cost-effective. Niosomes allow the prolonged release of the drug and film was used to increase the bioavailability of drugs via the sublingual route of drug administration. Fast dissolving niosomal films have great importance during emergency conditions like allergy, short-term spasm, and asthma whenever an immediate onset of action is required. Fast dissolving films are also suitable for pediatric, geriatric, and dysphasic patients or patients with fear of choking.

Keywords

Fast-dissolving drug–delivery, Geriatric, Solvent casting, Pediatric, Bioavailability.

Full Text

     

Keshav Dhiman ¹, Anshul Sharma ¹, Anshul Sharma ¹, Kamya Goyal ², Vinay Pandit ¹, M. S. Ashawat ¹, Shammy Jindal ¹

Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN

Abstract

The plants containing berberine have been used for the treatment of skin diseases, inflammatory disorders, and reducing fevers, wound healing, digestive and respiratory diseases and in treatment of tumors. By taking the specific properties of the berberine, this review describes the method mentioned in the literature regarding the berberine extraction. Furthermore, many experimental and clinical studies suggest that berberine has several pharmacological activities such as antioxidative, cardioprotective, nephroprotective, and hepatoprotective effect. This review summarizes the information about botanical occurrence, traditional uses and pharmacological effects of berberine and berberine containing plants.

Keywords

Berberine, Skin Diseases, Psoriasis.

Full Text