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Gayatri Ramya, M.
- ICH Guideline Practice- A Validated Stability- Indicating HPLC Method for the Determination of Efavirenz in Dosage Form
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Telangana University, Nizamabad – 503322, IN
2 Department of Pharmaceutics, Acharya Nagarjuna University, Nagarjuna Nagar- 522 510, IN
3 Department of Pharmaceutics and Pharmaceutical Analysis, Hindu College of Pharmacy, Guntur -522002, IN
4 Department of Pharmaceutics, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh -500008, IN
1 Department of Pharmaceutical Chemistry, Telangana University, Nizamabad – 503322, IN
2 Department of Pharmaceutics, Acharya Nagarjuna University, Nagarjuna Nagar- 522 510, IN
3 Department of Pharmaceutics and Pharmaceutical Analysis, Hindu College of Pharmacy, Guntur -522002, IN
4 Department of Pharmaceutics, Shadan College of Pharmacy, Hyderabad, Andhra Pradesh -500008, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 1 (2014), Pagination: 7-14Abstract
A simple, precise, accurate and new stability-indicating reversed-phase high-performance liquid chromatographic (RPHPLC) method was developed and validated as per International Conference on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines to determine efafirenz in tablet dosage form. The drug was successfully eluted at 6.264 min by mixture of ammonium dihydrogen phosphate buffer, acetonitrile and triethylamine (30:70:1) on C18 column (150 mm × 4.6 mm, 5 μm) at the flow of 1.5 ml/min. Drug content was determined in between 99.79% and 100.33% with standard deviation of 0.217. The validated RP-HPLC method may be successfully applied for assay, dissolution studies, bio-equivalence studies, as well as routine analysis in pharmaceutical industries.Keywords
RP-HPLC, Efavirenz, ICH.- Synthesis of Chalcones and Evaluation of Their Anti-Microbial Activity
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Authors
Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, IN
2 University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-500510, IN
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, IN
2 University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-500510, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 1 (2014), Pagination: 26-32Abstract
Chalcones are main precursor for biosynthesis of flavonoids which are frequent components of human diet. Recent studies on biological evaluation of chalcones revealed some Anticancer, Anti inflammatory, Anti mitotic, Anti tubercular, Cardiovascular, cell differenciation inducing, nitric oxide regulation modulatory and hyperglycaemic activities. This present research includes synthesis of varies chalcones from 5-acetyl salicylamide and evaluation of their anti microbial activity. Objective:
1. To synthesize chalcones using different catalyst solid NaOH.
2. Characterize chalcones using TLC, NMR, MASS and IR spectrometry.
3. To evaluate the anti-microbial activity .