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Niranjan Babu, M.
- Chronopharmaceutics as a Novel Approach for Clinically Relevant Drug Delivery System
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Authors
Affiliations
1 Seven Hills College of Pharmacy, Tirupati, 517 561, A.P., IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
1 Seven Hills College of Pharmacy, Tirupati, 517 561, A.P., IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 6 (2012), Pagination: 309-317Abstract
Chronopharmaceutics has been described as a branch of pharmaceutics devoted to the design and evaluation of drug delivery system that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given drug therapy. The circadian clock acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24h cycles. Diseases such as hypertension, asthma, peptic ulcer, arthritis, etc, follow the body's circadian rhythm. The goal in drug delivery research is to develop formulations to meet therapeutic needs relating to particular pathological conditions. Research in the chronopharmacological field has demonstrated the importance of biological rhythm in drug therapy, and this has brought a new approach to the drug delivery systems. The application of biological rhythm to pharmacotherapy may be correlated by the appropriate timing of dosing of these drug delivery systems to synchronize drug concentrations to rhythms in disease state.Keywords
Chronopharmaceutics, Bioactive Agent, Circadian Clock, Circadian Rhythm, Chronopharmacological, Pharmacotherapy.
- A Review on Buccal Drug Delivery System
Abstract Views :284 |
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Authors
Affiliations
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, IN
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati- 517561, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 3 (2017), Pagination: 109-113Abstract
Bio adhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to biological surface for an extended period of time. Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. The buccal mucosa is considered to be a promising site for the systemic delivery of drugs where a rapid onset of action is required and for drugs that are not easily administered via other routes than by injection. The buccal mucosa being a highly vascularised area helps in rapid systemic absorption of the drug, thereby avoiding hepatic “first-pass effect” of drugs leading to quicker onset of action, which could be especially important in the management of crisis situations like cardiac arrest, epileptic seizures, severe nausea and vomiting. This article aims at reviewing on buccal drug delivery system which includes the mechanism and factors affecting buccal absorption and the methods to increase drug delivery via buccal route.Keywords
Bioadhesion, Buccal Mucosa, First-Pass Effect, Cardiac Arrest, Epileptic Seizures.References
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