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Uppala, Praveen Kumar
- Formulation and Evaluation of Israpidine Extended Release Matrix Tablets
Authors
1 Bhaskara Institute of Pharmacy, Affiliated to Andhra University, Vizianagaram, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 4 (2016), Pagination: 277-291Abstract
The purpose of this study was to formulate and evaluate an efficient Isradipine extended release matrix tablets designed to provide 24 hours drug release profile using varying proportion of hydrophilic polymers viz; Lactose monohydrate and HEC as matrix-forming material. Prepared matrix tablets showed satisfactory physicochemical properties where drug content was 98.24% to 101.06 %, thickness was 3.33 mm to 3.55 mm, hardness was 7.52±0.171 to 8.94±0.285 kg/cm2 , friability was less than 1% and % weight variation was within the standard pharmacopoeial limits of ±7.5% of the weight. Mathematical analysis of the release kinetics of the optimized formulation (F15) was best fitted in zero order kinetics (R2 = 0.9743). The dissolution profiles of formulation F15 and innovator product in multi media were compared in pH 4.5 acetate buffer, pH 6.8 phosphate buffer, 0.1N HCl respectively. The stability data reveals that the F15 showed a negligible change in drug content after storage in various conditions for two months according to ICH guidelines.Keywords
Isradipine, Matrix Tablets, Lactose Monohydrate, HEC, Extended Release.
- Formulation and Evaluation of Extended Release Tablets of Alfuzosin HCl
Authors
1 K.V.K College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 2 (2014), Pagination: 91-98Abstract
Developing oral extended release tablets for highly water soluble drugs with constant release rate has always been a challenge to the pharmaceutical technologist. The present work is focused on controlling the release of highly water soluble Alfuzosin HCl from hydrophylic matrices prepared using hypermellose.
Alfuzosin HCl tablets were prepared by direct compression method using hypermellose polymer to control release of highly water soluble drug alfuzosin HCl which is having short half life primarily used as antihypertensive drug. The formulations developed from F1 to F8 .With in these formulations F8was found to have optimised drug release of 86% for 20 hours, the kinetic release studies were conducted for the optimised formulation and the best fit model was found to be Higuchi( diffusion ) model.