Research Journal of Pharmaceutical Dosage Form and Technology

Preethi Sudheer ¹, H. V. Ramesh Babu ², Soosamma John ²

Affiliations
1 Department of Pharmaceutics, East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN
2 East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN

Abstract

Lipid microspheres of ketoprofen was prepared by emulsification method using waxes such as bees wax, carnauba wax and cetosteryl alcohol. These microspheres were evaluated for in-vitro dissolution studies, thin layer chromatography, scanning electron microscopy and particle size analysis. Lipid microspheres were studied for diffusion characteristics using cellophane membrane and permeation characteristics through excised rat abdominal skin. Lipid microspheres were found to increase the rate of permeation of poorly absorbable ketoprofen, so they may be used as a potential carrier in increasing the rate of absorption in case of topical delivery of drugs.

Keywords

Lipid Microspheres, Ketoprofen, Emulsification, Diffusion.

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Shyamala Bhasakran ¹, Preethi Sudheer ¹

Affiliations
1 Department of Pharmaceutics, East Point College of pharmacy, Bidsrshalli, Virgo Nagar Post, Bangalore-560049, IN

Abstract

The present study is carried out to compare matrix tablets and mini tablets of Diltiazem hydrochloride. Matrix tablets and mini-matrix tablets containing Diltiazem hydrochloride have been prepared by wet granulation technique. The hydrophilic matrix was formed with chitosan together with the additives. Preparation, the swelling and erosion behavior, in-vitro release profiles and release kinetics and mechanism of release are discussed. Comparison of all the parameters of matrix and mini matrix tablets is discussed. The result shows that mini matrix tablets shows more extended release profile in comparison with the matrix tablets under similar conditions.

Keywords

Matrix Tablets, Chitosan, Minitablets, Diltiazem Hydrochloride.

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