Research Journal of Pharmaceutical Dosage Form and Technology

Rajendra Jangde ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010

Abstract

Article reviews the surge of research focus, potential opportunities and challenges available in new area of colon targeted drug delivery system. Most of drugs are absorbed from upper part of GIT tract. Lack of digestive enzymes and long transit time, has been provided to design colon specific drug delivery system and review is aimed at understanding recent advancements made in multiparticulate formulation approaches, matrix, multilayer and compression coated tablets to reach colon intact to be investigated by approaches for targeting through pH sensitive system, Microbially triggered system i.e., prodrugs and polysaccharide based system, Timed release system, osmotically controlled drug system, pressure dependent release system, programmed pulsatile release system etc., Although oral delivery has become a widely acceptable route of administration, GI tracts presents several formidable barrier to drug delivery. In addition life cycle management, patient compliance, improved stability and optimization of drug absorption process are some key drivers for developing alternative delivery system of drugs.

Keywords

Colon Targeted Drug Delivery, pH Sensitive, Time Controlled Dependent, Pressure Controlled, Osmotically Controlled.

Full Text

     

Rajendra Jangde ¹, Rahul Singhour ², S. J. Daharwal ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, IN
2 Aristo Pharmaceutical Mandideep, Bhopal (M.P.), IN

Abstract

Proper formulation is an important aspect of any dosage form design. FTIR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

Keywords

Gatifloxacin, FTIR, Differential Scanning Calorimetry, Pharmaceutical Excipents, Preformulation Compatibility.

Full Text