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Co-Authors
- Shubham Tripathi
- Umesh Kumar Sahu
- Jyotsana Meshram
- D. K. Tripathi
- Ajazuddin
- Amit Alexander
- Harish Sharma
- Gyanesh Kumar Sahu
- Kritika Kanoujia
- Chandraprabha Dewangan
- AyushI Masih
- Dipti Sinha
- Divya Oraon
- Manisha Jaiswal
- Monika Sahu
- Sapna Pradhan
- Ravi Suman
- Rajkishan Dewangan
- Roman Banjare
- Pradeep Paikra
- Mukesh Rawtiya
- Mukta Agrawal
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kumari, Ranjeeta
- Formulation and Characterization of Virgin Coconut Oil Emulsion (VCOE) for Treatment of Alzheimer’s Disease
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Authors
Shubham Tripathi
1,
Umesh Kumar Sahu
1,
Jyotsana Meshram
1,
Ranjeeta Kumari
1,
D. K. Tripathi
1,
Ajazuddin
1,
Amit Alexander
1,
Harish Sharma
2,
Gyanesh Kumar Sahu
1
Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka Kurud Road, Bhilai, IN
2 Shri Shankaracharya technical campus, Shri Shankaracharya group of institution, Faculty of Pharmacy, Junwani, Bhilai, IN
1 Rungta College of Pharmaceutical Sciences and Research, Kohka Kurud Road, Bhilai, IN
2 Shri Shankaracharya technical campus, Shri Shankaracharya group of institution, Faculty of Pharmacy, Junwani, Bhilai, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 49-54Abstract
Alzheimer’s disease, is a somatic disease that affects the brain. It is a progressive disease that destroys memory and other important mental functions. During this disease, accumulation of cerebral extracellular amyloid, which is mostly composed of accumulated amyloid-β (Ab) peptide as well as the accumulation of intracellular neurofibrillary tangles, appears to start up. This results in the loss of connection between nerve cell, and lead to the degeneration of neurons and finally death of brain tissue. Also due to the deficiency of some important chemical messenger in the brain, the signal transmission gets ultimately, affected in the body. The main objective of this study was to prepare the optimized formula of a VCO based emulsion containing Tween 20 as the surfactant for treatment of Alzheimer’s disease which may help to increase the cholesterol level in the brain and to destroy the β amyloid plaque as a result of which the level of chemical messenger will increase in the brain. This study is further aimed to analyze, concentration of drug reaching into the brain and to study its effect in destroying β amyloid plaque.Keywords
Amyloid-β, Chemical Messengers, Neurofibrillary, Tangles, Peptide, Cholesterol.
References
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- VaibhavKumar Dapurkar, Harish Sharma, Gyanesh Kumar Sahu, Swati Meshram, Dr. GopalRai, Anti arthritic activity of ischolar_mains extract of boerhaaviadiffusa in adjuvant induced arthritis rats, Scholar academic journal of pharmacy 2013 2(2): 107-109.
- GyaneshKumar Sahu, Harish Sharma, Anshita Gupta, Chanchal Deep Kaur, A review article on advancement in microemulsion based drug delivery system for better therapeutic effect, International journal of pharmaceutical sciences and developmental research , Aug 2015.
- GyaneshKumar Sahu, Harish Sharma, VaibhavKumar Dapurkar, An over view of new drug delivery system: microemulsion, International research journal of pharmaceutical and applied science, 2012 2(5): 1-8
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- GyaneshKumar Sahu, Harish Sharma, ChanchalDeep Kaur, A novel approach of magnetic modulated microspheres, Asian J. of research, 2013, vol III, Issue 4, page 220-224.
- Gyaneshkumarsahu, Harish sharma, Dr. GopalRai, Vaibhav Kumar Dapurkar, Development and evaluation of methotreaxate loaded BSA microsphere, International research journal of pharmaceutical and applied science, 2012; 2(5); 9-12.
- Bony R. Shah, DhruboJyotiSen, Rajesh Bahekar. Design, Synthesis and Pharmacological Evaluation of Potent and Selective Dipeptidyl-Derived Inhibitors as New Class of Antidiabetic Drugs. Asian J. Research Chem. 4(1): January 2011; Page 50-54.
- SunitaSoni, Ajay Soni, Sunil Ganatra. Studies on the Optimum Reaction Time for Commercial Cholesterol kits. Asian J. Research Chem. 6(10): October 2013; Page 950-951.
- K. Hemalatha, V. Chakkaravarthi, K. Ganesa Murthy, R. Kayatri, K. Girija. Molecular Properties and Docking Studies of Benzimidazole Derivatives as Potential Peptide Deformylase Inhibitors. Asian J. Research Chem. 7(7): July 2014; Page 644-648.
- Rajesh Yadav, Nita. Yadav, MurliDharKharya. Steroid Chemistry and Steroid Hormone Action: A Review. Asian J. Research Chem. 7(11): November, 2014; Page 964-969.
- SandeepPokharia. An Atoms-in-molecules (AIM) interpretation of organotin-peptide system: I. Di-n-butyltin(IV) derivative of glycyltryptophane. Asian J. Research Chem. 2017; 10(2): 115-118.
- Gangadhara MM, Dinesha R, Satish Kumar Murari. A noncytotoxic pseudo peptide KL1 with potent antioxidant activity. Asian J. Research Chem. 2017; 10(2): 127-130.
- D. M. SuyogaVardhan, H. K. Kumara, H. Pavan Kumar, D. Channe Gowda. Urea and Thiourea Derivatives of Dipeptides Conjugated Piperazine Analogue as A New Class of AGE's Inhibitors: Synthesis and Molecular Docking Studies. Asian J. Research Chem. 2017; 10(4): 459-469.
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- Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug
Abstract Views :501 |
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Authors
Kritika Kanoujia
1,
Chandraprabha Dewangan
1,
AyushI Masih
1,
Dipti Sinha
1,
Divya Oraon
1,
Manisha Jaiswal
1,
Monika Sahu
1,
Ranjeeta Kumari
1,
Sapna Pradhan
1,
Ravi Suman
1,
Rajkishan Dewangan
1,
Roman Banjare
1,
Pradeep Paikra
1,
Mukesh Rawtiya
1,
Mukta Agrawal
1,
Ajazuddin
1,
D. K. Tripathi
1,
Amit Alexander
1
Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 10, No 2 (2018), Pagination: 95-102Abstract
The oral route is most preferred one as there is ease of administration and it is a painless approach. This favored route is restricted to those drug molecules that are absorbent over gastric mucosa. One of the promising techniques is SMEDDS. Self-micro emulsifying drug delivery system has gained more attention due to enhanced oral bioavailability enabling a reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug towards specific absorption window in GIT, and protection of drugs from the unreceptive environment in the gut. SMEDDS provide the dissolved drugs form,and also its small size of droplets imparts substantial interfacial area for the absorption of drugs. It can simply get penetrated into the GIT which is the major advantages over another emulsion. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.Keywords
SMEDDS, Oral Drug Delivery, GIT, Solubility, Bioavailability.References
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