Research Journal of Pharmaceutical Dosage Form and Technology

V. Kalyani ¹, V. Sai Kishore ¹, U. Kartheek ¹, S. Aruna ¹, A. Navya Krishna ¹

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur District, IN

Abstract

In the present study, natural gums (Hibiscus rosa-sinensis mucilage and Modified gum karaya) were investigated as superdisintegrants for use in immediate release tablet formulations containing olanzapine. Immediate release tablets of olanzapine were formulated using different concentrations (2, 3, 4, 5) of natural superdisintegrant viz; Hibiscus rosa - sinensis mucilage and modified gum karaya. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. The formulated tablets had good appearance and better drug release properties. Modified gum karaya showed shorter disintegration time and showed 100% release is selected as optimized formulation. Immediate release tablet formulations containing modified gum karaya showed better dissolution efficiency property than the most widely used synthetic superdisintegrants. The dissolution rate followed first-order kinetics as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of Olanzapine was found to be effected by the concentration of the superdisintegrant used in the preparation of tablets. The formulation (F4) prepared with 5%w/w of modified gum karaya was offered relatively rapid release of Olanzapine when compared with other concentrations employed in this investigation. The difference factor (f1) and similarity factor (f2) were calculated for marketed formulation and for formulations prepared with modified gum karaya. The difference factor (f1) and similarity factor (f2) were found to be 12 and 68 respectively. Similarity factor (f2) is more than 50 and difference factor (f1) is less than 15, hence dissolution profiles are found to be similar.

Keywords

Olanzapine, Modified Gum Karaya, Hibiscus Rosa-Sinesis, Crospovidone.

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A. Navya Krishna ¹, Y. Deepthi ¹, S. Aruna ¹, T. E. G. K. Murthy ¹

Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), A.P.-522101, IN

Abstract

The present work is to formulate and evaluate liquisolid compacts of Atorvastatin calcium. Atorvastatin calcium is an anti hyperlipedmic drug belongs to class of statins. The bioavailability is 14% due to dissolution rate limitation and its biological half life is 14 hours. The solubility of Atorvastatin was enhanced by liquid solid compact technology. So the aim of this work is to increase the solubility and in-vitro dissolution of practically insoluble drug Atorvastatin, liquisolid tablet consists of lactose (flowlac), cab-o-sill and PG as liquid vehicle. The prepared formulations were evaluated for drug content, weight variation, hardness, friability, disintegration, dissolution. The better drug release was observed from the F8 formulation (1:5) containing (flowlac) Atorvastatin 20 mg, carrier 505.65 mg, coating material 10mg, and super disintegrating and lubricants 11.64, 23.45 were added. The selected formulation was evaluated for stability studies.

Keywords

Atorvastatin Calcium, Liquisolid Compacts, Carrier, Coating Material, In-Vitro Dissolution, Bioavailability.

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