Research Journal of Pharmaceutical Dosage Form and Technology

Dode Raj H. ¹, Surawase Rajendra K. ¹

Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan – 423501, Dist.- Nashik, (MH), IN

Abstract

The nanosuspension is one of the technology that can enhance the solubility of the poorly soluble drugs. It is an fine dispersion of the equal sized solid particles in an aqueous vehicle. The current objective of this work is to develop and evaluate nanosuspension of Albendazole, a poorly water-soluble anthelmintic drug, to enhance the solubility as well as the dissolution. The nanosuspension were formulated by nanoprecipitation with ultrasonication method using formic acid as solvent and water as anti-solvent. The formulated nanosuspensions were evaluated for particle size, drug entrapment efficiency, total drug content and the saturation solubility studies. In this study nine batches were formulated by using two different polymers that are PVP K-30 and Poloxamer 407 and as a surfactant SLS in which the concentration of the polymers was varied. The results of thepre formulation studies that are melting point 210-212oC, UV spectroscopic and FTIR studies proved that the drug was pure. The nanoparticles of Albendazole showed particle size in range of 0.005-0.020m. On the basis of the total drug content and drug entrapment efficiency formulation F7 showed the excellent results.

Keywords

Nanosuspension, Albendazole, Polymers, Nanoprecipitation, Particle Size, Solubility.

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Bagul Mahesh B ¹, Surawase Rajendra K. ²

Affiliations
1 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH), IN
2 Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal. Kalwan - 423501, Dist. Nashik, (MH)

Abstract

This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.

Keywords

Zinc Gluconate, Vitamin C, Effervescent tablet, Immunity, Wet granulation method

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