Research Journal of Pharmaceutical Dosage Form and Technology

Prakash N Kendre ¹, Syed N. Lateef ¹, Rahul K. Godge ¹, Mahendra A. Giri ¹, Bharat D. Pagare ¹, Ritesh D. Patel ¹

Affiliations
1 Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar Kopargaon, Ahmednagar, (M.S.), IN

Abstract

The objective of this study was to formulate and evaluate a matrix system for sustained and simultaneous delivery of two anti-asthmatic drugs Salbutamol sulphate and Theophylline which is often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making prolonged release formulation necessary.

The matrix tablets were prepared by wet granulation method using hydroxypropyl methylcellulose (HPMC K15M, K4M; HPC and Carbapol 934P) in various percentages. The granules showed satisfactory flow properties and compressibility. All the five tablet formulations showed acceptable pharmacotechnical properties and complied with the in-house specifications for tested parameters. The release rate could efficiently be modified by varying the matrix forming polymer, the use of polymer blends and the addition of water soluble or water insoluble fillers (such as dicalcium phosphate, lactose or mannitol). The tablets swelled and eroded upon contact with release medium. Fitting the in-vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.

Keywords

Matrix System, Erosion, Hydroxypropylmethylcellulose, Antiasthmatic etc.

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Rahul K. Godge ¹, Syed N. Lateef ², Mahendra A. Giri ², Pravin D. Chaudhari ³, Abhijeet N. Merekar ¹, Prakash N. Kendre ⁴

Affiliations
1 Pravara Rural college of Pharmacy, Pravaranagar Dist. Ahemadnagar, IN
2 Sanjivani college of Pharmaceutical Edu. and Research, Kopargaon, IN
3 Modern College of Pharmacy, Nigadi, Pune, IN
4 Dept. Pharmaceutics, Sanjivani College of Pharmaceutical Edu. & Research, Kopargaon Dist. Ahemadnagar (M.S.), IN

Abstract

The aim of the study was to develop and physicochemicaly characterize single unit controlled delivery system of Rosiglitazone maleate and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbapol 934P). Formulation was optimized on the basis of buoyancy and in vitro drug release profile. Also tablets were tested for various tests like hardness, thickness, weight variation, friability, swelling index and erosion index. The tablets swelled and eroded upon contact with release medium (0.1 N HCl) at 37 0C. The release rate could efficiently be modified by varying the matrix forming polymer, the use of polymer blends and the addition of water soluble or water insoluble fillers (such as dicalcium phosphate, lactose or mannitol). Fitting the in-vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.

Keywords

Rosiglitazone Maleate, Carbapol, HPMC, Floating Matrix Tablets, Swelling Index, Buoyancy.

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