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Mahajan, Vijay R.
- Liquisolid Compact Techniques: A Review
Abstract Views :270 |
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Authors
Affiliations
1 Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nasik, IN
1 Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nasik, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 3 (2014), Pagination: 161-166Abstract
Oral drug administration has been one of the most convenient and widely accepted route of delivery for most of the therapeutic agents. It is one of the most extensively used routes of drug administration because of its obvious advantages of ease of administration, improved patient compliance, and convenience. The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, "powdered solution technology" or "Liquisolid technology", has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. The limited solubility of drugs is a challenging issue for industry, during the development of the ideal solid dosage form unit. Liquisolid technique is a novel and promising approach to overcome this consequence. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. The selection of non toxic hydrophilic solvent, carrier, coating materials and its ratios are independent of the individual chemical moieties. The increased bioavailability is due to either increased surface area of drug available for release, an increased aqueous solubility of the drug, or improved wettability of the drug particles.Keywords
Liquisolid System, Carrier Material, Coating Material, Non-volatile Solvents, Compact.- Floating Drug Delivery System (FDDS): An Overview
Abstract Views :177 |
PDF Views:0
Authors
Affiliations
1 S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, IN
1 S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 3 (2014), Pagination: 174-182Abstract
In recent years scientific and technological advancements have been made in research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence time (GRTs) and unpredictable gastric emptying time, etc. To overcome these limitations, various approaches have been proposed to increased gastric residence of drug delivery systems in upper part of the gastrointestinal tract includes floating drug delivery system(FDDS), swelling or expanding systems, mucoadhesive systems, magnetic systems, modified-shape systems, high density system and other gastric emptying devices. Among these systems, FDDS have been most commonly used. These dosage forms can be retained in the stomach for prolonged period of time in a predetermined manner. Gastroretentive drug delivery technology is one of the promising approach for enhancing the bioavailability and controlled delivery of drugs that exhibit narrow absorption window. This manuscript highlights various developmental approaches, characterization aspects, potential drug candidates, advantages and applications of gastroretentive systems.Keywords
Floating Drug Delivery Systems, Gastric Residence Time, Swelling Index, Buoyancy.- Liquisolid Compact Techniques:A Review
Abstract Views :228 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nasik, IN
1 Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nasik, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 4 (2014), Pagination: 161-166Abstract
Oral drug administration has been one of the most convenient and widely accepted route of delivery for most of the therapeutic agents. It is one of the most extensively used routes of drug administration because of its obvious advantages of ease of administration, improved patient compliance, and convenience. The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, "powdered solution technology" or "Liquisolid technology", has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. The limited solubility of drugs is a challenging issue for industry, during the development of the ideal solid dosage form unit. Liquisolid technique is a novel and promising approach to overcome this consequence. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. The selection of non toxic hydrophilic solvent, carrier, coating materials and its ratios are independent of the individual chemical moieties. The increased bioavailability is due to either increased surface area of drug available for release, an increased aqueous solubility of the drug, or improved wettability of the drug particles.Keywords
Liquisolid System, Carrier Material, Coating Material, Non-Volatile Solvents, Compact.- Floating Drug Delivery System (FDDS):An Overview
Abstract Views :213 |
PDF Views:0
Authors
Affiliations
1 S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, IN
1 S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 4 (2014), Pagination: 174-182Abstract
In recent years scientific and technological advancements have been made in research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence time (GRTs) and unpredictable gastric emptying time, etc. To overcome these limitations, various approaches have been proposed to increased gastric residence of drug delivery systems in upper part of the gastrointestinal tract includes floating drug delivery system(FDDS), swelling or expanding systems, mucoadhesive systems, magnetic systems, modified-shape systems, high density system and other gastric emptying devices. Among these systems, FDDS have been most commonly used. These dosage forms can be retained in the stomach for prolonged period of time in a predetermined manner. Gastroretentive drug delivery technology is one of the promising approach for enhancing the bioavailability and controlled delivery of drugs that exhibit narrow absorption window. This manuscript highlights various developmental approaches, characterization aspects, potential drug candidates, advantages and applications of gastroretentive systems.Keywords
Floating Drug Delivery Systems, Gastric Residence Time, Swelling Index, Buoyancy.- Self-Emulsifying Drug Delivery Systems (SEDDS): A Brief Review
Abstract Views :186 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi Hills, Dhamangaon Tal. Igatpuri, Dist. Nashik (MS), IN
1 Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Nandi Hills, Dhamangaon Tal. Igatpuri, Dist. Nashik (MS), IN