Research Journal of Pharmaceutical Dosage Form and Technology

Pankaj Savani ¹, Vineet Jain ², Hasumati Raj ¹, Sagar Patel ¹

Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN

Abstract

Clopidogrel Bisulphate is a mainly use in Anti platelet agent as a ADP receptor blocker and administration of oral tablet dosage form. Chemically, it is Methyl 2-(2- Chlorophenyl) -2-(6, 7-dihydro thieno [3,2-C] Pyridine- 5(4H)-yl) Acetate sulphate. It is used in the treatment of various cardiovascular diseases like Ischemic stroke as well as in Glomerular inflammation, Myocardial infarction, Atherosclerosis disease, Unstable Angina. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. These reviews of analytical methods including Spectrophotometric methods like Spectrophotometry, Chromatographic method including HPLC, HPTLC were reported.

Keywords

Clopidogrel Bisulphate, Analytical Methods, Compendial Method, UV Spectroscopic Method, Chromatographic Methods.

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Paras Virani ¹, Rajanit Sojitra ¹, Hasumati Raj ², Vineet Jain ²

Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN

Abstract

A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 226.00 nm and 246.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 μg/ml at their respective λmax. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.033μg/ml and 0.125 μg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 0.1008 μg/ml and 0.3792 μg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 99.75 % and 99.52% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.

Keywords

Irbesartan, Atorvastatin, Simultaneous Estimation, Simultaneous Equation Method, Analysis Method.

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