Research Journal of Pharmaceutical Dosage Form and Technology

Rihan Jawed ¹, Wajid Ahmad ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR

Abstract

Current research is focused on formulation and evaluation of natural gum based fast dissolving tablet of Cefixime trihydrate by applying 32 factorial designs for the improvement of the drug absorption. Direct compression method was used. Two factors as independent variable (x1) Fenugreek mucilage(x2) sodium saccharin glycolate were taken with three level (+1, 0,-1). The level two factors were selected on basis of preliminary experiments conducted and their effect on dependent variable (disintegration time) was estimated. Formulated tablets were evaluated for parameters in which the values were found to be in the range of hardness 2.1-2.6 kg/cm2 , thickness 2.227-2.296 mm, weight variance 182-196 mg, wetting time 58-68 seconds, waterabsorption ratio 0.1628-0.2439, disintegration time 56 sec – 9 min, and friability 0.53-0.68 %. The software design expert (11.0) was used for getting experimental design, modeling the response surface and calculating the static evaluation. The tablet parameters tests of formulation (F1 to F10) were observed within prescribe limit. Disintegration time observed 56 seconds, % cumulative drug release 88.79 % to 98.90 %. Batch F6 was observed as promising batch.

Keywords

Cefixime trihydrate, Fenugreek mucilage powder, Fast Dissolving tablets, Pharmaceutical excipients.

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Rihan Jawed ¹, Wajid Ahmad ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR

Abstract

The study of microorganism is called microbiology, which includes bacteria, viruses, fungi and Protozoa. Microbes play a major role in this field. Microbes are also used for life-saving drugs etc. The effect of ultraviolet rays on the bacteria’s are mostly lethal to them, UV is a minor fraction of the solar spectrum reaching the ground surfaces, the UV light radiation will reduce the microbes in the surroundings as well as in the labs. The aim of this study was to evaluate the effect of the ultraviolet rays on pathogenic bacteria’s. Three organisms were selected for the study. Staphylococcus aureus and Streptococcus faecalis. 30 watts UV tube was used to evaluate the antibacterial activity of the UV radiation. The exposure time was determined as 5, 10 and 15 mins at a close distance of 10cm. 20 microliter of suspension was taken and mixed in 2 ml of sterile normal saline and exposed for respective duration. Sub culture was done on suitable media after the exposure. Time exposed plates were incubated at 37 degree Celsius overnight and checked for the total CFU and data were tabulated. The Ultra violet radiation of pathogenic bacteria resulted in a significant total colony forming unit. Ultraviolet rays were lethal to the bacteria’s. There are many airborne bacteria’s surrounded by environment ultraviolet rays exposure will cause an apparent decrease in the pathogenic bacteria’s.

Keywords

Bacteria, Effect, Eco friendly, Pathogenic and Ultraviolet, Innovative technology, Innovative technique.

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Wajid Ahmad ¹, Rihan Jawed ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR

Abstract

A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1% Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20-µl. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Levamisole was performed (10-60µg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively The range of 10-60µg /ml was selected for the linearity of a standard Levamisole. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study.Linearity studies for Levamisole was performed on (10-60µg/ml).

Keywords

RP-HPLC, Levamisole, Methanol, Ortho Phosphoric Acid.

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Wajid Ahmad ¹, Rihan Jawed ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR

Abstract

The present study aimed to develop an immediate release of Zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug releasewere found to be more than 60% in 15 minutes. This present studies concluded that Zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameters, it was concluded that the FJ5 formulation was found to be optimized formulation.

Keywords

Oral Jelly, Migraine, Zolmitriptan Hydrochloride, Chitosan Hydrochloride.

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Wajid Ahmad ¹, Rihan Jawed ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR

Abstract

The objective of present study was to prepare alginate beads of antihistamine meclizine hydrochloride for sustain release action. The alginate beads were prepared by employing sodium alginate as a polymer with sodium carboxymethyl cellulose and chitosan hydrochloride as release retardant. The method of preparation employed was ionotropic gelation. The prepared beads were seen having the drug release rate of 98.34% of A4 batch and 99.02% of B4 batch in the time period of 12hrs. The maximum percent drug content of 94.72±0.06% was found in A4 batch. From the results it can be seen that A4 batch was found to be optimum as it was having maximum drug content and maximum amount of drug release in the predicted time period of 12hrs. Themicrobeads of meclizine hydrochloride by using ionotropic gelation method were prepared successfully employing various polymers in different concentrations. The prepared microbeads can be a better alternative than various other sustained release dosages forms.

Keywords

Meclizine hydrochloride, Ionotropic Gelation, Anti-Histamine, Microbeads, Antiemetics.

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Wajid Ahmad ¹, Rihan Jawed ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR

Abstract

Novel drug delivery systems are the method for delivering of the medications to patients in such a manner which increases concentration of medications inside various body parts. The drug delivery widely found over nanomedicines that plan for employing nano particles mediated drugs delivery for combating downfall for the conventional drug delivery. The nano particles that loaded along with drug and target for the specific part of body where it must solely diseased tissues, hence by avoiding interactions along with the healthy tissues. The aim of targeted drugs delivery system is for the prolonged, localizing, and targeting and has the protected drugs interactions along with diseased tissues. The conventional drugs delivery systems are absorption of drugs around the biological membrane, the targeted releases systems release the drugs in the form of dosage. The pharmaceuticals innovation such as newer drugs delivery system presents the health professional along with wider range of the arsenal for treating disease with better efficacy, precision and the safety. In the future, it is hopeful that along with the more researches endeavor that focused in the arena in the coming future, a larger portion of conventional dosages form be replaced by the betterment of the health care delivery that expected to change over. The pharmacovigilance will provide the cost-efficient health care that helped for extending the better health care for underprivileged.

Keywords

Delivery, Drug, Newer, Novel, System, Tissues.

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Wajid Ahmad ¹, Rihan Sheikh ¹, Razia Ahmad ¹, Suhana Khan ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR

Abstract

Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. The short half life and high frequency of administration of drug makes it a suitable candidate for designing sustained drug delivery system. The aim of the present investigation was to develop a sustained release matrix tablet of Rifaximin using sodium alginate and cross linked sodium alginate and to evaluate the drug release kinetics. In order to achieve the required sustained release profile, the tablets were prepared by a wet granulation method. The formulated tablets were characterized for pre-compression and post-compression parameters and they were in the acceptable limits. The drug release data obtained after an in vitro dissolution study was fitted to various release kinetic models in order to evaluate the release mechanism and kinetics. The criterion for selecting the best fit model was linearity (coefficient of correlation). Drug release mechanism was found to follow a complex mixture of diffusion, swelling and erosion. The dosage form holds the potential to control the release rate of drug and extend the duration of action of a drug.

Keywords

Verapamil HCl, Matrix Tablet, Cross Linking, Sodium Alginate, Drug Release.

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Wajid Ahmad ¹, Rihan Sheikh ¹, Razia Ahmad ¹, Suhana Khan ¹

Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR

Abstract

Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor waterdissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method,Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.

Keywords

Solubility Enhancement, Drug Release, Nanocrystallization, BCS, Novel Techniques.

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Wajid Ahmad ¹, Jaza Quazi ¹

Affiliations
1 Department of Pharmaceutical Science, Institute of Pharmacy, Ankara, TR

Abstract

This review assesses the use of Calendula officinalis extract in antihyperlipidemic activities, cardiovascular activities, antidiabetic, hepatoprotective activities; anthelmintic activities; antioxidant activities; anti inflammatory activities; wound healing activities; anticancer activities; hepatoprotective activities, antibacterial activities; and anti-HIV activities. C. officinalis extract has been shown to have some remedial effects and has been used in herbal remedies, according to this review. To examine the effect of calendula officinalis, larger as well as well-designed random control trials are needed. Calendula officinalis is a flowering plant that comes under the Asteraceae family. This herb is used as curative in Europe, China, and India. It's been the subject of anumber of chemical and pharmacological research, and it's also known as "African marigold." It's commonly utilized in indigenous medicine to treat jaundice, wound recovery, plasma cleansing, and spasmolytic treatment. A vast range of chemicals, including amino acids, triterpenoids, coumarines, quinones, flavonoids, volatile oils, and carotenoids, have been found through chemical analysis.

Keywords

Calendula officinalis, African marigold, pharmacological research, homoeopathy, Pot marigold.

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