Effect of Alcoholic Extract of Stem Bark of Anamirta cocculus Willd on Central Nervous System

Anamirta cocculus Willd is a well known medicinal plant belonging to the family Menispermaceae. Its ethanolic extract was evaluated for locomotor activity, analgesic activity and muscle relaxant activity. The rotarod apparatus was used for evaluation of muscle relaxant activity. The extract showed significant decrease in fall off time which indicated that it has CNS depressant activity when compared with diazepam. Photoactometer was used to study of locomotor activity in mice. The effects were found to be dose dependent statistically significant when compared with control groups. Hot plate was used to study of analgesic activity of extract. The reaction time was increased in the extract treated groups than that of morphine as standard drug. The antipyretic activity of extract was investigated experimental rats. The antipyretic was retained in all the dose of extract tested was comparable to that of paracetamol as standard drug.