Research Journal of Pharmacognosy and Phytochemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

In-vitro Screening of Ficus racemosa for Anticancer Activity


Affiliations
1 JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, India
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, India
3 Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, India
     

   Subscribe/Renew Journal


Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).

Keywords

Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 198

PDF Views: 0




  • In-vitro Screening of Ficus racemosa for Anticancer Activity

Abstract Views: 198  |  PDF Views: 0

Authors

Prakash S. Sukhramani
JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, India
G. Vidyasagar
Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, India
Piyush M. Patel
Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, India

Abstract


Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).

Keywords


Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.