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An Evaluation of Anti-Pyretic Potential of Vetiveria zizanioides (Linn.) Root


Affiliations
1 Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Buldana Road, Malkapur, Dist Buldana-443101, India
2 Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India
     

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Vetiveria zizanioides belonging to the family Gramineae, is widely used as a traditional plant as refrigerant that cools and calms the entire body. The current study was focused to evaluate the antipyretic (yeast-induced pyrexia in albino rats) potential of the hexane extract (HEVZ) and methanol extract (MEVZ) of Vetiveria zizanioides ischolar_main. The yeast-induced pyrexia method was standardized by subcutaneous injection of yeast suspension (10 ml/kg body wt.) which increased rectal temperature after 17 hours followed by recording of rectal temperature at regular interval. Both extract at 75mg, 150mg and 300mg/kg dose significantly (P<0.05) reduced yeast-induced elevated temperature. Also the effect of extracts on normal body temperature was evaluated. Rectal temperature of rodents was recorded at a time interval of 1hrs, 2hrs, 3hrs, 4hrs and 5hrs after drug administration. Reduction is in a dose dependent manner.The anti-pyretic effect of HEVZ and MEVZ was comparable to that of a standard antipyretic agent paracetamol (150 mg/kg body wt, p.o).

Keywords

Antipyretic Activity, Vetiveria zizanioides, Yeast-Induced Pyrexia.
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  • An Evaluation of Anti-Pyretic Potential of Vetiveria zizanioides (Linn.) Root

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Authors

M. B. Narkhede
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Buldana Road, Malkapur, Dist Buldana-443101, India
P. V. Ajmire
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India
A. E. Wagh
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India
M. R. Bhise
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India
G. D. Mehetre
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India
H. J. Patil
Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, India

Abstract


Vetiveria zizanioides belonging to the family Gramineae, is widely used as a traditional plant as refrigerant that cools and calms the entire body. The current study was focused to evaluate the antipyretic (yeast-induced pyrexia in albino rats) potential of the hexane extract (HEVZ) and methanol extract (MEVZ) of Vetiveria zizanioides ischolar_main. The yeast-induced pyrexia method was standardized by subcutaneous injection of yeast suspension (10 ml/kg body wt.) which increased rectal temperature after 17 hours followed by recording of rectal temperature at regular interval. Both extract at 75mg, 150mg and 300mg/kg dose significantly (P<0.05) reduced yeast-induced elevated temperature. Also the effect of extracts on normal body temperature was evaluated. Rectal temperature of rodents was recorded at a time interval of 1hrs, 2hrs, 3hrs, 4hrs and 5hrs after drug administration. Reduction is in a dose dependent manner.The anti-pyretic effect of HEVZ and MEVZ was comparable to that of a standard antipyretic agent paracetamol (150 mg/kg body wt, p.o).

Keywords


Antipyretic Activity, Vetiveria zizanioides, Yeast-Induced Pyrexia.