Effect of Phyllanthus niruri Leaf Extract on Antioxidant Activity and UV Induced Chromosomal Aberration in Swiss Albino Mice

In the recent study of investigation, the genotoxic effect of leaf extract of Phyllanthus niruri has been analysed against UV- induced chromosomal aberration in the bone marrow cells of mice. Single i.p. administration of Phyllanthus niruri leaf extract at three different doses namely 250, 500 and 750 mg/kg b. wt. have provided protection when given 24 hr prior to the exposure of Ultra Violet radiation (UV B, 315 nm). A dose inhibition of chromosomal aberration was observed which was statistically significant (p<0.05) as compared to the UV treated group. In another set of experiment, the antioxidant activity of Phyllanthus niruri leaf extract using Fenton reaction was also observed and we found a dose dependent inhibition of Thiobarbituric acid reactive substance (TBARS) as compared to positive control. The minimum inhibitory concentration 50% of P. niruri and DMSO was found to be 68.76 and 56.98 respectively. Its seems to have a preventive potential against UV induced chromosomal aberrations in the bone marrow cells of the mice and also found antioxidant activity. Therefore, the results suggest a genotoxic and antioxidant potential of Phyllanthus niruri leaf extract.