Research Journal of Pharmacognosy and Phytochemistry

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Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats


Affiliations
1 Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, India
2 Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, India
3 Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, India
4 Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, India
5 Departement of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, India
     

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Methanolic extracts of Vitex quinata ischolar_mains at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata ischolar_mains at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.


Keywords

Vitex quinata, Antioxidant Activity, Ascorbic Acid.
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  • Hepatoprotective Activity of Vitex quinata Roots against Paracetamol-Induced Hepatic Injury in Rats

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Authors

V. Sreedhar
Deparment of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, India
L. K. Ravindra Nath
Department of Chemistry, Srikrishna Devaraya University, Anantapur, A.P, India
N. Madana Gopal
Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, India
K. Venu Gopal
Dept of Pharmacy, Nirmala College of Pharmacy, Kadapa, A.P, India
D. Raju
Department of Pharmacy, Prabhath Institute of Pharmacy, Nandayal, A.P, India
K. K. Rajasekhar
Departement of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, A.P, India

Abstract


Methanolic extracts of Vitex quinata ischolar_mains at 200, 400 and 800 mg/kg and silymarin was prepared and tested for its hepatoprotective effect against paracetamol induced hepatitis in rats. Alteration in the level of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, TPL, CHL, TPTN and ALP were tested in both treated and untreated groups. The methanolic extracts of Vitex quinata ischolar_mains at 200,400 and 800 mg/kg and silymarin showed a significant (P<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (P<0.05) in TPTN and ALB levels produced by the toxicant Paracetamol.


Keywords


Vitex quinata, Antioxidant Activity, Ascorbic Acid.