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Anti-Inflammatory and Anti-Nociceptive Activity of Pandanus tectorius Parkinson


Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala, Punjab, India
2 Rayat and Bahra Institute of Pharmacy, Hoshiarpur, Punjab, India
3 PCTE Institute of Pharmacy, Jhande, Ludhiana, Punjab, India
     

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Pandanus tectorius (Pandanaceae) was being used ethnomedically for treatment of diseases like asthma, cough, and bronchitis and locally as analgesic. Chemical constituents of leaves included triterpene, squalene and phytosterols. The study was aimed to evaluate both anti-inflammatory and anti nociceptive activity of the ethanolic extract of fresh leaves of Pandanus tectorius (PTEE) in rats using the carrageenan-induced paw oedema method in rats and tail-flick model in mice at various dose levels. Ceiling effect of the extract was observed at 300 mg/kg in carrageenan test. The effect was equivalent to phenylbutazone (80 mg/kg, p.o.) at 300 mg/kg. Effectiveness of extract in the late phase of inflammation suggests the inhibition of prostagalandins and leukotrienes release. The extract produced marked analgesic activity at 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg, p.o). Preliminary phytochemical screening revealed the presence of tannins, sterols, triterpenes and flavanoids in extract. In conclusion, this study has established the anti-inflammatory activity and analgesic activity of P. tectorius and, thus, justifies the ethnic uses of the plant.

Keywords

Pandanus, Pandanaceae, Anti-Inflammatory, Antinociceptive.
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  • Anti-Inflammatory and Anti-Nociceptive Activity of Pandanus tectorius Parkinson

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Authors

Vikas Gupta
National Institute of Ayurvedic Pharmaceutical Research, Patiala, Punjab, India
Junaid Niazi
Rayat and Bahra Institute of Pharmacy, Hoshiarpur, Punjab, India
Jatinderjot Kaur Kehal
PCTE Institute of Pharmacy, Jhande, Ludhiana, Punjab, India
Parveen Bansal
National Institute of Ayurvedic Pharmaceutical Research, Patiala, Punjab, India

Abstract


Pandanus tectorius (Pandanaceae) was being used ethnomedically for treatment of diseases like asthma, cough, and bronchitis and locally as analgesic. Chemical constituents of leaves included triterpene, squalene and phytosterols. The study was aimed to evaluate both anti-inflammatory and anti nociceptive activity of the ethanolic extract of fresh leaves of Pandanus tectorius (PTEE) in rats using the carrageenan-induced paw oedema method in rats and tail-flick model in mice at various dose levels. Ceiling effect of the extract was observed at 300 mg/kg in carrageenan test. The effect was equivalent to phenylbutazone (80 mg/kg, p.o.) at 300 mg/kg. Effectiveness of extract in the late phase of inflammation suggests the inhibition of prostagalandins and leukotrienes release. The extract produced marked analgesic activity at 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg, p.o). Preliminary phytochemical screening revealed the presence of tannins, sterols, triterpenes and flavanoids in extract. In conclusion, this study has established the anti-inflammatory activity and analgesic activity of P. tectorius and, thus, justifies the ethnic uses of the plant.

Keywords


Pandanus, Pandanaceae, Anti-Inflammatory, Antinociceptive.