Research Journal of Pharmacognosy and Phytochemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root


Affiliations
1 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
3 SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India
4 Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India
     

   Subscribe/Renew Journal


Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum ischolar_main. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.

Keywords

Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.
Subscription Login to verify subscription
User
Notifications
Font Size


  • The Wealth of India, a Dictionary of Indian Raw Materials and Industrial Products, C.S.I.R., New Delhi (India). 1952; 3: 195.

  • Kirtikar K. R., Basu B. D., Indian medicinal plants, International Book Distributors, Dehradun.1991; 3(3); 1730.

  • Vasudesan N. V., In Indian Medicinal Plants, Vol. IV, Orient Longman Ltd, Chennai. 1995: 172.

  • Deeaph G., Malti G., Indian Drugs. 1994; 31: 294.

  • Ambasta S.P., The Useful Plants of India, Publications and Information directorate, New Delhi CSIR. 1986: 409.

  • Nasar E.L.S.M.M., Comparisons of Convolvulus lantus and C.arvensis. Fitoterapia. 1982; 53: 189-191.

  • Sahabuddin, Triterpenois from the stem of Operculina turpethum L. J. Biol. Sci.1999; 8: 157-163.

  • The Ayuyrvedic Pharmacopoiea, Govt. of India, Ministry of health and family welfare, New Delhi, 1(2): 133.

  • Khalid H. J., Anwar H. G., Evaluation of the protective potential of Artemisia maritime extract on acetaminophen and CCl4 induced liver damage. Journal of Ethnopharmacology. 1995; 47: 43-47.

  • Porchezhian E., Ansari S.H., HepatoprotectiveactivityofAbutilon indicum on experimental liver damage in rats. Phytomedicine.2005; 12: 62–64.

  • Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma gaertn. Ind.J.Nat.Prod. 1998; 3: 14.

  • Bahar A., Tanveer A., Shah A. K., Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. 2001; 76: 187–189.

  • Galighor A.E., Kozloff E.N., Essentials of practical micro technique, second edition, Lea and Febiger, New York1976; 210.

  • Fakurazi, S., I. Hairuszah, J.M. Lip and G. Shanthi, The effect of pretreatment of zerumbone on fatty liver following ethanol induced hepatotoxicity. J. Biol. Sci. 2008: 8: 1348-1351


Abstract Views: 606

PDF Views: 0




  • Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root

Abstract Views: 606  |  PDF Views: 0

Authors

Vrunda V. Shah
Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India
Vipul K. Shah
Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
Krishnkant N. Patel
SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India
Navin R. Sheth
Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India
M. M. Patel
Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India

Abstract


Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum ischolar_main. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.

Keywords


Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.

References