Research Journal of Pharmacognosy and Phytochemistry

Malarkodi Velraj ¹, Ranjit Singh ², B. Rathore ², V. Ravichandiran ², S. Jayakumari ², Sanjay Ragala ²

Affiliations
1 Vels University, School of Pharmaceutical Sciences, Department of Pharmacognosy, Old Pallavaram, Chennai-116, IN
2 Vels University, School of Pharmaceutical Sciences, Department of Pharmacognosy, Old Pallavaram, Chennai-116, IN

Abstract

Madhuca indica J.F.G. mel belongs to the family "Sapotaceae". It is a much valued herbal medicine used for Rheumatism, Ulcers, itches, bleeding, spongy gums, tonsillitis and diabetes mellitus. The present study report its anatomical, microscopical, quantitative characters, powder microscopy, histochemical, fluorescence analysis, physiochemical standards, preliminary phytochemical standards and thin layer chromatography. The study revealed important diagnostic character which can be used for identification of the plant.

Keywords

Madhuca indica, Transverse Longitudinal Section, Radial Longitudinal Section.

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Malarkodi Velraj ¹, Mahendra Singh ², V. Ravichandiran ², S. Jayakumari ², A. Vijayalakshmi ², Sanjay Ragela ²

Affiliations
1 Dept. of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN
2 Department of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN

Abstract

In the present study, coarse powder of Scindapsus officinalis (Roxb.) Schott. fruit was extracted successively using hexane, chloroform, ethyl acetate and 50% ethanol. The ethyl acetate and 50% ethanolic extracts were investigated for its antioxidant activity by using nitric oxide and DPPH radical scavenging methods. The IC₅₀ value was also calculated. Ascorbic acid was used as a standard. Both 50% ethanolic and ethyl acetate extract were found to exert concentration dependent free radical scavenging activity but former extract was more effective than the later on. The highest free radical scavenging activity by Scindapsus officinalis fruit extracts was observed at concentration of 1000 μg/ml.

Keywords

Scindapsus officinalis (Roxb.) Schott., Antioxidant, Free Radicals, IC₅₀ Value.

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Malarkodi Velraj ¹, A. Vijayalakshmi ², S. Jayakumari ², S. Ramamoorthy ², V. Ravichandiran ², J. Srikanth ³

Affiliations
1 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai–117, Tamil Nadu, IN
2 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, IN
3 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IN

Abstract

The present study was designed to investigate the antidepressant effects of Albizzia lebbeck leaves in various animal depression models. The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck leaves (200 and 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/kg. p.o) and fluoxetine (20mg/kg.p.o). The leaf extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST.

The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Our results suggested that the ethanolic extract of Albizzia lebbeck leaves exerts antidepressant-like effect.

Keywords

Albizzia lebbeck, Depression, Forced Swim Test, Tail Suspension Test.

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Malarkodi Velraj ¹, Armstrong ¹, Ravichandran ¹, Jeyakumari ¹, Hemalatha ¹, Vijayalakshmi ¹, J. Srikanth ²

Affiliations
1 Department of Pharmacognosy, VELS College of Pharmacy, VELS University, Pallavaram, Chennai-600 043, Tamil Nadu, IN
2 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, IN

Abstract

Soymida febrifuga is commonly known as Shem in Tamil and Indian red wood in English. In Ayurveda the bark is used as a good cure for ulcer, leprosy and dysentery. In unani the bark is used as an astringent to the bowel and useful in fever. The bark is also used in vaginal infection, rheumatic swellings, oedema, wounds, dental problems, uterine bleeding and malarial fever. There was no report on the pharmacognostic study of the plant and hence the present investigation deals with the anatomical, microscopical, powder microscopy, physio-chemical, fluorescence analysis, Thin layer chromatography and high performance thin layer chromatography. The study revealed the presence of drugs of calcium oxalate, tannins dilated phloem rays, sieve elements and schlerids. Phytochemical studies showed the presence of steroids, terpenoids, flavanoids and tannins.

Keywords

Soymida febrifuga, TLS, RLS.

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