Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals


Affiliations
1 Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
2 Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India
3 Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India
     

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The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid-induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant.

Keywords

Analgesic, Anti-inflammatory, Carrageenan, Acute Toxicity, Solanum Surattense
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  • Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals

Abstract Views: 279  |  PDF Views: 2

Authors

K. Sravanthi
Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
K. V. Ramana
Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India
G. Sumalatha
Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
K. Neeraja
Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India

Abstract


The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid-induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant.

Keywords


Analgesic, Anti-inflammatory, Carrageenan, Acute Toxicity, Solanum Surattense

References