Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals


Affiliations
1 Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
2 Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India
3 Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India
     

   Subscribe/Renew Journal


The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid-induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant.

Keywords

Analgesic, Anti-inflammatory, Carrageenan, Acute Toxicity, Solanum Surattense
Subscription Login to verify subscription
User
Notifications
Font Size


  • Tripathi. K.D .Essentials of Medical Pharmacology. 4th Edition, published by Jaypee Brothers, New Delhi, 2002; 612-614.

  • Singh N, Kapur KK and Singh SP. Mechanism of cardiovascular action of Terminalia arjuna . J Med Plant Res. 1982; 45:102-104.

  • The Ayurvedic Formulary of India, Part-II, 2000, 1st edition, The Controller of Publications, Delhi, p.35.

  • Baydar NG, Ozkan G, Sagdic O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Control 2004; 15:335-339.

  • Akoh CC, Bonilla EP, Sellappan S, Krewer G. Phenolic content and antioxidant capacity of Muscadine grapes. Journal of Agricultural and Food Chemistry 2003; 51:5497-5503.

  • Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. The Lancet 1993; 341(20):454- 457.

  • Mayer AS, Yi OS, Person DA, Waterhouse DL, Frankel EN. Inhibition of human low density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). Journal of Agricultural and Food Chemistry 1997; 45:1638-1643.

  • Teissedre PL, Frankel EN, Waterhouse AL, Peleg H, German GB. Inhibition of in vitro human LDL oxidation by phenolic antioxidants from grapes and wines. Journal of the Science of Food and Agriculture 1996; 70:55-61.

  • Waterhouse AL. Wine antioxidants may reduce heart disease and cancer. Presentation of American Chemical Society, Washington; 1994.

  • Renaud S, Lorgeril MD. Wine, alcohol, platelets and the French paradox for coronary heart disease. The Lancet 1992; 339:1523- 1526.

  • Davalos A, Bortolome B, Gomez-cordoves C. Antioxidant properties of commercial grape juices and vinegars. Food Chemistry 2005; 93(2):325-330.

  • Orhan DD, Orhan N, Ergun E, Ergun F. Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. Jornal of Ethnopharmacology 2007; 112:145-151.

  • Corder R, Mullen W, Khan NQ, Marks SC, Wood EG, Carrier MJ, Crozier A. Red wine procyanidins and vascular health. Nature 2006;444:566.

  • Mishra S. Bhaisazya Kalpana Vigyan. Varanasi, India: Chaukambha Surbharati Prakashan; 2005.p. 253-254.

  • Alam M, Radhamani S, Ali U, Purushottam KK. Microbiological Screening of Dhataki Flowers. Journal of Research in Ayurveda and Siddha 1984; 2(4):371-375.

  • Braugghler JM, Duncan CA and Chase IR. The involvement of iron in lipid peroxidation. J Biol Chem. 1986; 261(22): 10282- 89.

  • Lowery OH, Rosenbrough NJ, Farr AL and Randall RJ. Protein estimation with Folin phenol reagent. Biol Chem. 1951;193:265-275.

  • Khanna AK, Chander R and Kapoor NK. Terminala arjuna: an Ayurvedic cardiotonic, Regulates lipid metabolism in Hyperlipidemic rats. Phytother Res. 1996;10: 663-665.

  • Allain CC, Poon LS, Chan CS and Richmond W. Enzymatic Determination of Total Serum cholesterol. Clin Chem .1974;20::447-475.

  • Friedewald WT, Levy RI and Fredrickson DS. Estimation of concentration of low density cholesterol in plasma without use of ultracentrifuge. J Clin Chem .1972;18: 449-502.

  • Muller PH, Schmulling RM, Liebich HM and Eggstein M. A fully Enzymatic Triglyceride Determination. J Clin Chem. 1977;15:457-464.

  • Anne SM, Ock SY, Debra AP, Andrew LW and Edwin NF. Inhibition of Human Low Density Lipoprotein oxidation in relation to composition of Phenolic antioxidants in Grapes (Vitis Vinifera). J Agri Food Chem. 1997;45 (5):1638-1643.

  • S Renaud, and M De Lorgeril. Wine, alcohol, Platelets and the French Paradox for Coronary Heart Disease. The Lancet. 1992; 339: 1523-1526.

  • Pederson TR. Low- density lipoprotein cholesterol lowering is and will be the key to the future of lipid management. American J Cardiol. 2001; 87(5A): 8B-12B.

  • Boden WE and Pearson TA. Raising low levels of High Density Lipoprotein Cholesterol is an important target of therapy. American J cardiol. 2000; 85(5):645-650.


Abstract Views: 352

PDF Views: 2




  • Evaluation of Anti-inflammatory and Analgesic potency of Whole Plant Extract of Solanum surattense in Experimental Animals

Abstract Views: 352  |  PDF Views: 2

Authors

K. Sravanthi
Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
K. V. Ramana
Department of Pharmacognosy, A. S. N College of Pharmacy, Guntur, (A.P), India
G. Sumalatha
Department of Pharmacology, Hindu College of Pharmacy, Guntur, (A.P), India
K. Neeraja
Department of Pharmacology, Calcutta institute of pharmaceutical t A.H.S, Kolkata, India

Abstract


The anti-inflammatory effect of the alcoholic extract of Solanum surattense whole plant was assessed in the carrageenan-induced rat paw edema, the antinociceptive effect of the alcoholic extract of Solanum surattense, plant was studied using thermal and chemical-induced pain models using animals, at the doses of 100 and 200 mg/kg body weight. The acute toxicity and the phytochemical constituents of the extract were also determined. The estimated LD50 of the extract was 2gm/kg body weight. Extract significantly (P<0.05), dose-dependently demonstrated anti-inflammatory activity against acute inflammation induced by carrageenan and also the extract significantly (P<0.05) prolonged the pain reaction times in tail flick pain model, and reduced acetic acid-induced writhing. Phytochemical analysis revealed the presence of alkaloids, saponins, flavanoids and carbohydrates in the plant.

Keywords


Analgesic, Anti-inflammatory, Carrageenan, Acute Toxicity, Solanum Surattense

References