Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

In-vitro Antiprotozoal Activity of Zizyphus jujuba Mill and Lamk


Affiliations
1 Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India
     

   Subscribe/Renew Journal


Zizyphus jujuba Mill and Lamk. Is also called as Baer tree, belongs to the family Rhamnaceae. The dried bark was powdered and extracted with various solvents by successive soxhlet hot extraction process with increasing order of polarity. On phytochemical investigation, the different extracts has shown the presence of carbohydrates, alkaloids, steroids, flavonoids and tannins. The different extracts were screened for antiprotozoal activity on Entamoeba histolytica and Giardia lamblia using metronidazole as standard drug. Both acetone and methanol extract showed significant antiprotozoal activity compared to standard drug metronidazole.

Keywords

Antiprotozoal Activity, Zizyphus jujuba, Metronidazole, Entamoeba histolytica, Giardia lamblia.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Dr. Nadkarni K M. Indian Materia Medica. Popular Prakshan Private Limited, Mumbai. 2000; (1):1316-1317.

  • Kirtikar K R, Basu B D. Indian Medicinal Plants. International Book Distributors, Dehradun. 2005; (1):589-591.

  • Al-Reza SM, Bajpai VK, Kang SC. Evaluation of antioxidant and antilisterial effect of seed essential oil and organic extracts from Zizyphus jujuba. Food Chem Toxicol. 2009 Sep; 47(9):2374-80.

  • Gupta M, Mazumder UK, Vamsi ML, Sivakumar T, Kandar CC. Evaluation of anti-steroidogenic activity of ethyl acetate extract of Zizyphus jujuba bark on mice. Journal of Ethnopharmacol. 2004 Jan; 90(1):21-5.

  • Ganachari M S; Shiv Kumar. Effects of Zizyphus jujuba leaf extract of body weight, food intake and serum lipid levels in sucrose induced obese rats. Indian Journal of Pharmaceutical Sciences 2004; 66(3):363-365.

  • Jiang JG, Huang XJ, Chen J. Isolation and purification of saponins from Zizyphus jujuba and their sedative and hypnotic effects. Journal of Pharm Pharmacol. 2007 Aug; 59(8):1175-80.

  • Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. Evaluation of anxiolytic effect of seed of Zizyphus jujuba in mouse models. Journal of Ethnopharmacol. 2000 Oct; 72(3):435-41.

  • Huang X, Kojima-Yuasa A, Norikura T, Kennedy DO, Hasuma T, Matsui-Yuasa I. Mechanism of anti-cancer activity of Zizyphus jujuba in HepG2 cells. Am J Chin Med. 2007; 35(3):517-32.

  • Pandey MB, Singh AK, Singh JP, Singh VP, Pandey VB. Isolation of three new cyclopeptide alkaloids from Zizyphus species. Journal of Asian Natural Products Res. 2008 Jul-Aug; 10(7-8):719-23.

  • Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. Central Drug Research Institute, Lucknow and National Institute of Science Communication, New Delhi. 1980; (3):694.

  • Liu QX, Wang B, Liang H, Zhao YY, Liu MJ. Structure identification of jujuboside D from Zizyphus jujuba Mill var. Spinosa. Yao Xue Xue Bao. 2004 Aug; 39(8):601-4.

  • Bai YJ, Cheng G, Tao J, Wang B, Zhao YY, Liu Y, Ma LB, Tu GZ. Structure identification of jujuboside D from Zizyphus jujuba Mill var. Spinosa. Yao Xue Xue Bao. 2003 Dec; 38(12):934-7.

  • The Wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. Publication and Information Directorate Council of Scientific and Industrial Research, New Delhi. 2003; (11):111.

  • Tempone AG, Borborema SET, Andrade HF, Gualda NCA, Yogi A, Carvalho CS,et al. Antiprotozoal Activity of Brazilian Plant Extracts from Isoquinoline Alkaloids-producing Families. Phytomed 2005; 12:382-390.

  • Iqbal P F. Chemical Investigation of New Antiprotozoal agents. PhD thesis Abstract, Jamia Millia Islamia, New Delhi 2008.

  • Calzada F, Mulia L Y, Contreras A T, Ortega A. Antiprotozoal and Antibacterial Properties of Decachaeta incompta. Rev Latinoamer Quim 2009; 37(2):97-1-3.

  • Brijesh S, Daswani PG, Tetali P, Anita NH, Birdi TJ. Studies on Dalbergia sissoo leaves: Possible Mechanism of Action in Infectious Diarrhea. Indian J Pharmacol 2006; 38(2):120-124.

  • Croft SL. The Current Status of Antiparasitic Chemotherapy. Parasitology Cambridge 1997; 114:3-15.

  • Fevrier A, Ferreria ME, Fournet A, Yaluff G, Inchausti A, de Arias A R. Acetogenins and other Compounds from Rolliniu emurginutu and Their Antiprotozoal Activities. Planta Medica 1999; 65:47-49.

  • Shibumon G, Benny P J, Antiprotozoal Activity of crude Extract of Flacourtia inermis by Microscopic Count Method. International J Pharmaceutical and Biological Archives 2010; 1(4):385-388.


Abstract Views: 420

PDF Views: 2




  • In-vitro Antiprotozoal Activity of Zizyphus jujuba Mill and Lamk

Abstract Views: 420  |  PDF Views: 2

Authors

Veeresh
Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India
S. Kambhoja
Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India
M. S. Nagraj
Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India
Manjunath
Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India
Vishesh
Department of Pharmacognosy, The Oxford College of Pharmacy, Hongasandra, Bangaluru-560068, India

Abstract


Zizyphus jujuba Mill and Lamk. Is also called as Baer tree, belongs to the family Rhamnaceae. The dried bark was powdered and extracted with various solvents by successive soxhlet hot extraction process with increasing order of polarity. On phytochemical investigation, the different extracts has shown the presence of carbohydrates, alkaloids, steroids, flavonoids and tannins. The different extracts were screened for antiprotozoal activity on Entamoeba histolytica and Giardia lamblia using metronidazole as standard drug. Both acetone and methanol extract showed significant antiprotozoal activity compared to standard drug metronidazole.

Keywords


Antiprotozoal Activity, Zizyphus jujuba, Metronidazole, Entamoeba histolytica, Giardia lamblia.

References