Research Journal of Pharmacology and Pharmacodynamics

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Use of Triggers to Detect Adverse Drug Reactions of Gastrointestinal Tract in Outpatient Department


Affiliations
1 University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik (MS) 420 004, India
2 University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik, India
     

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The use of "triggers", clues to identify Adverse Drug Events (ADEs) is an effective method for measuring the overall level of harm from medications in a health care organization. The use of multiple medications is a serious problem in current health care system. To detect the Adverse Drug Reactions (ADR) in gastrointestinal drugs by using trigger tool methodology was done in civil hospital and one of the private hospital of Nashik city. It includes enrolment of the patient in Out Patient Department (OPD) according to Inclusion Criteria (IC) and Exclusion Criteria (EC). The patient was selected by using consecutive sampling method. Written informed consent was taken from recruit patient by using informed consent form. Once the informed consent was obtained, patient's prescription was studied and was followed every 7 days by telephonic conversation and every month in OPD. Prescription was studied and analysed by observing the prescription of the patient by using predetermined triggers associated with possible adverse drug event for next seven days. After finding specific trigger we kept record of all finding on ADE report form. Total number of prescriptions was considered and total number of Triggers was calculated in percentage .Total number of positive triggers which had shown ADR was calculated accordingly. Out of 180 sample size total triggers were found to be 15 (8.3%), and ADR reported to be 7 (3.8%). We found 8 (4.4%) such triggers which could not detect any ADR. Improving trigger tools and applying them in analyzing the ADR will surely detect the ADR and reduce the risk and harms in patients.

Keywords

Gastrointestinal System, Adverse Drug Reaction, Trigger Tool, Adverse Drug Event.
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  • Vikas dhikav et al., Adverse drug reaction monitoring in India Journal, Indian Academy of Clinical Medicine 2004; 1:27 -33.

  • Wiffen P, Gill M, Edwards J, Moore A: Adverse drug reactions in hospital patients. A systematic review of the prospective and retrospective studies. Bandolier Extra 2002, 1-16.

  • Lazarou J,Pomeranz B.H., Corey, P.N. JAMA, 5/2/2001; 279(15); 1200; 1998. Originally posted 6/12/2004; Revised 2006-01-10.

  • Shashindran and B.Gitanjali, Adverse Drug Reaction Monitoring Health Administrator Vol: XIX Number 1: 20-21.

  • Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45.

  • Forster AJ, Murff HJ, Peterson JF, Gandhi TK, Bates DW (2003) the incidence and severity of adverse events affecting patients after discharge from the hospital. Ann Intern Med 138:161-167 2003.

  • K.D Tripathi Text Book of Pharmacology. Jaypee Brothers Medical Publishers Ltd New Delhi, 2003.

  • Griffin FA, Resar RK. IHI Global Trigger Tool for Measuring Adverse Events. IHI Innovation Series white paper. Cambridge, Massachusetts: Institute for Healthcare Improvement; 2007.

  • J D Rozich, C R Haraden, R K Resar- Adverse drug event trigger tool: a practical methodology for measuring medication related harm: Qual Saf Health Care 2003; 12; 194 - 200.

  • Himanshu Sharma et al., A pharmacovigilance study in the department of medicine of a university teaching hospital: Pharmacy Practice 2007; 5(1): 46-49.

  • Hillary J. Mull, MPP1, Jonathan R. Nebeker - Informatics Tools for the Development of Action-Oriented Triggers for Outpatient Adverse Drug Events AMIA . 2008; 505-509.

  • Michael N Cantor, Henry J Feldman, Marc M Triola-Using trigger phrases to detect adverse drug reactions in ambulatory care notes: Qual Saf Health Care 2007; 16:132-134.

  • Kerry Butler et al., Eliminating Adverse Drug Events at Ascension Health The Joint Commission Journal on Quality and Patient Safety2007; 33(9):527-535.

  • Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm. 1992; 27:538.

  • IHI Global Trigger Tool for Measuring Adverse Events (UK version). Institute for Healthcare Improvement. September 2008, 3.


Abstract Views: 265

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  • Use of Triggers to Detect Adverse Drug Reactions of Gastrointestinal Tract in Outpatient Department

Abstract Views: 265  |  PDF Views: 2

Authors

A. S. Khairnar
University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik (MS) 420 004, India
P. M. Patil
University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik, India
N. U. Patil
University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik, India
P. R. Gade
University Department of Interpathy Research and Technology, Maharashtra University of Health Science, Nashik, India

Abstract


The use of "triggers", clues to identify Adverse Drug Events (ADEs) is an effective method for measuring the overall level of harm from medications in a health care organization. The use of multiple medications is a serious problem in current health care system. To detect the Adverse Drug Reactions (ADR) in gastrointestinal drugs by using trigger tool methodology was done in civil hospital and one of the private hospital of Nashik city. It includes enrolment of the patient in Out Patient Department (OPD) according to Inclusion Criteria (IC) and Exclusion Criteria (EC). The patient was selected by using consecutive sampling method. Written informed consent was taken from recruit patient by using informed consent form. Once the informed consent was obtained, patient's prescription was studied and was followed every 7 days by telephonic conversation and every month in OPD. Prescription was studied and analysed by observing the prescription of the patient by using predetermined triggers associated with possible adverse drug event for next seven days. After finding specific trigger we kept record of all finding on ADE report form. Total number of prescriptions was considered and total number of Triggers was calculated in percentage .Total number of positive triggers which had shown ADR was calculated accordingly. Out of 180 sample size total triggers were found to be 15 (8.3%), and ADR reported to be 7 (3.8%). We found 8 (4.4%) such triggers which could not detect any ADR. Improving trigger tools and applying them in analyzing the ADR will surely detect the ADR and reduce the risk and harms in patients.

Keywords


Gastrointestinal System, Adverse Drug Reaction, Trigger Tool, Adverse Drug Event.

References