Research Journal of Pharmacology and Pharmacodynamics

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To Study the Effect of Allium Sativum on Various Biochemical Parameters on Stress Induced in Albino Rats


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1 Luqman College of Pharmacy, Gulbarga, Karnataka, India
     

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The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.

Keywords

Swimming, Cold Stress, Allium sativum, WBC, BUN.
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  • To Study the Effect of Allium Sativum on Various Biochemical Parameters on Stress Induced in Albino Rats

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Authors

S. Roshan
Luqman College of Pharmacy, Gulbarga, Karnataka, India
B. Tazneem
Luqman College of Pharmacy, Gulbarga, Karnataka, India
Abdullah Khan
Luqman College of Pharmacy, Gulbarga, Karnataka, India
Sadath Ali
Luqman College of Pharmacy, Gulbarga, Karnataka, India

Abstract


The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.

Keywords


Swimming, Cold Stress, Allium sativum, WBC, BUN.

References