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Roy, Amit
- Screening of Anti-Inflammatory Potential of Berberis coriaceae Leaves by HRBC Membrane Stabilization
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Authors
Amit Roy
1,
Ram Kumar Sahu
2
Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.), IN
2 Oriental College of Pharmacy, Patel Nagar, Bhopal (M.P.), IN
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.), IN
2 Oriental College of Pharmacy, Patel Nagar, Bhopal (M.P.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 1 (2012), Pagination: 5-6Abstract
The present study was undertaken to screen anti-inflammatory activity of alcohol and aqueous extracts of leaves from Berberis coriaceae against HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. Both the extracts showed a biphasic effect on the membrane stabilization. Their activities are comparable to that of the standard drug diclofenac sodium. However their activities decreased with time.Keywords
Berberis coriaceae, HRBC, Diclofenac Sodium.
References
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- Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice
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Authors
Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 87-90Abstract
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.Keywords
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.References
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- Jagetia GC, Venkatesh P, Baliga MS (2005): Aegle marmelos (L.) Correa Inhibits the proliferation of Transplanted Ehrlich Ascites Carcinoma in mice. Biol. Pharm. Bulletin, 28(1), 58-64.
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- Morse EC, Stoner G (1996): Cancer chemoprevention: principles and prospects. Carcinogenesis, 14, 1737-1746.
- Lewis JG and Adams DO (1987): Early inflammatory changes in the skin of Sencer and C57B2/6 mice following exposure to 12-Otetradecanoyl phorbol-13-acetate. Carcinogenesis, 8, 889-898.
- Nugroho AE, Riyanto S, Sukari MA, Maeyama K (2010): Effects of Skimmianine, a quinoline alkaloid of Aegle marmelos Correa ischolar_mains, on the Histamine release from rat mast cells. Journal of Basic and applied Sciences, 6(2), 141-148.
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- Narendra T, Shweta S, Tiwari P, Reddy KP, Khaliq T, Prathipati P, Puri A, Srivastava AK, Chander R, Agarwal SC, Raj K (2007): Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. Bioorg Med Chem Letters, 17(6), 1808-1811.
- Meena PD, Kaushik P, Shukla S, Soni AK, Kumar M, Kumar A (2006): Anticancer and antimutagenic properties of Acacia nilotica (Linn) on 7, 12-dimethylbenz(a)anthracene induced skin papillomagenesis in Swiss Albino mice. Asian pacific Journal of cancer prevention, 7, 627-632.
- Sabu MC and Kuttan R (2004): Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian J. Physiol Pharmacology, 48(1), 81-88.
- Samarasekera I and Krishnamurti JK (2004): Isolation of various coumarin present in the various parts of the Aegle marmelos. Nat. Prod. Res., 18(2), 117-132.
- Singanan V, Singanan M and Begum H (2007): The hepatoprotective effect of Bael leaves (Aegle marmelos) in alcohol induced liver injury in Albino rats. International Journal of Science and Technology, 2(2), 83-92.
- Upadhya S, Shanbhag KK, G Suneetha, Naidu, Upadhya S (2004): A study of Hypoglycemic and antioxidant activity of Aegle marmelos in Alloxan induced diabetic rats. Indian Journal of Physiol Pharmacology, 48(4), 476-480.
- Ethnomedicinal Uses of Plants for Wound Healing in Khargone District, MP: A Survey over Nimari Communities
Abstract Views :264 |
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Authors
Affiliations
1 Department of Pharmaceutics, GRY Institute of Pharmacy, Borawan, Khargone-451228, IN
2 Columbia Institute of Pharmacy, Raipur, IN
1 Department of Pharmaceutics, GRY Institute of Pharmacy, Borawan, Khargone-451228, IN
2 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 1 (2014), Pagination: 21-29Abstract
Results of ethnomedicinal studies carried out in the state of Madhya Pradesh, India that lies between 22° 11' 0" North, 75° 35' 0" East are presented. The usage of wild plants by the nimari people for the cure of cuts and wounds is described. The use of 52 species belonging to 39 families have been enumerated. The plants not only contain antiseptic value but also have regenerative and healing properties. Leaves, fruit and seeds are crushed and applied as a paste and decoction in the combination of water, honey or coconut oil and powder made from fresh or dried material have been reported. In addition, preparations were taken internally by preparing mixture with Aloe vera and sugar.Keywords
Ethnomedicinal, Wounds, Antiseptic, Decoction.References
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- Preliminary Phytochemical Screening and In Vitro Antioxidant Properties of the Pleurotus ostreatus extract
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Authors
Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), IN
1 Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 135-138Abstract
The free radical amassed in the body due to oxidative stress, and plays the leading part in the inception of disease. Presently researchers are working on natural antioxidant, because it has minimum toxic effect compared to chemical substances. Pleurotus ostreatus extract were evaluated for phytochemical composition and to assess in vitro antioxidant activities. In the course of preliminary phytochemical analysis, the petroleum ether extract, ethyl acetate extracts and ethanol extracts of P. ostreatus was evaluated to determine the presence of secondary metabolites. Antioxidant activity of the ethanol extract of P. ostreatus was assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH), Super oxide free radical scavenging assay (SOD) and total polyphenol content. Preliminary phytochemical screening of ethanol extract revealed the presence of phenolic compounds, flavonoids, alkaloids and glycoside, while petroleum ether and ethyl acetate extracts were devoid from these phytoconstituent. The ethanol extract scavenged DPPH radical and superoxide radical with the IC50 being 69.30 μg/ml and 107.05 μg/ml respectively. The ethanol extract of P. ostreatus revealed 83.47 ± 1.53 mg/100 gm of total polyphenol content. The finding endorses that P. ostreatus acquire high antioxidant activities, and it may uses as natural antioxidant for the healing of various diseases.Keywords
Pleurotus ostreatus, DPPH, Antioxidant, Phytochemical.References
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