Research Journal of Pharmacology and Pharmacodynamics

Juna Thomas ¹, D. Veeresh Babu ¹, Anjan Kumar ¹, V. B. Narayana Swamy ²

Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN

Abstract

Aim: The present study was designed to evaluate the anti depressant activity of a Poly herbal formulation "PERMENT" in experimental animal models.

Method: Anti depressant activity was evaluated in experimental different either sex animal models. The degree of anti depressant activity was determined by measuring the immobility time in Forced swim test and Tail suspension test, by counting the number of failure to escape and number of avoidance response in Learned helplessness test, Reserpine induced test the rectal temperature is determined and the number of passages of rodents through the hole from one chamber to another in Hole cross as a confirmatory test.

Result: Animals treated with all three doses of PERMENT (53.85, 102.77 and 154.16mg/kg) witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with Imipramine (15mg/kg), as expected showed a significant decrease in the immobility time. In learned Helplessness Test, the PERMENT treated rats showed significant increase in avoidance response and decreased in escape failure in response to shock treatment. In Reserpine Induced Test the initial rectal temperature is determined by electronic thermometer. Hole cross test utilizes the number of passages of rodents through the hole from one chamber to another.

Conclusion: The study revealed that the "PERMENT" possess a significant anti depressant activity.

Keywords

PERMENT, Forced Swim Test, Tail Suspension Test, Reserpine Induced Test, Hole Cross Test.

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Sanu G. Sam ¹, Anjan Kumar ¹, D. Veeresh Babu ¹, V. B. Narayana Swamy ²

Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN

Abstract

The present study was designed to evaluate the antidiabetic and anti-inflammatory activity of ethanolic extract of whole plant of "Inula racemosa" using different animal models. Antidiabetic activity was evaluated by using various two animal models. The alloxan induced diabetes method and streptozocin induced diabetes method along with biochemical parameters like SALP, SGPT, SGOT, Triglycerides, Total proteins were employed to investigate antidiabetic potential of Inula racemosa. Anti-inflammatory activity was evaluated using formalin induced paw edema model and croton oil ear edema model. Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema. The study revealed that the whole plant of "Inula racemosa" possess a significant anti-diabetic and anti-inflammatory activity.

Keywords

Inula racemosa, Alloxan Induced Diabetes Method, Streptozocin Induced Diabetes Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema Model.

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