Research Journal of Pharmacology and Pharmacodynamics

Farhad Ahmadi ¹, Ardeshir Hafsy Kordestany ¹

Affiliations
1 Islamic Azad University, Sanandaj Branch, Kurdistan, IR

Abstract

This research was carried out to investigation of retention silver (Ag) in different organs and faeces of broiler chicks. A total of 160 one-day-old male broiler allocated in a randomized completely design (CRD) with four group (60 birds), four replicates and 10 broiler in each experimental pens. Experimental diets were included: A) Control (without nano-silver), B) control+5ppm nano-Ag/kg, C) control+1 Oppm nano-Ag/kg and D) control+l5ppm nano-Ag/kg and nano-Ag added to basal diet of broilers throughout research (21-42 days). At the end of study, from any treatments one bird with means's treatment selected and take sampling blood from wing vein and then slaughtered. Immediately after slaughtered, Visceral organs such as: Liver, heart, gizzard, spleen, pancreas, thymus, lungs and tight and breast muscle. Also, to determine rate of Ag in bird's faeces, samples were weekly taken during study and then dried, stored until analysis. Silver concentration in different tissues by using gamma radioactivity method has measured and Ag of rate expressed as ppb (Parts per billion) into different organs and feces. Results showed no significant difference among treatment point of view time saturation of tissues with silver and seem to be quickly distributed by blood circulation. Examination of different organs showed that Ag was accumulated in different tissues of broiler. The highest concentrations Ag were found in breast and leg muscles, spleen, pancreas, faeces, thymus and heart of muscles in the ranking order. We had significantly observed increasing trend concentration of Ag in different tissues corresponding to increase level of nano-silver among control and other group (p<0.01).

Keywords

Broiler, Oxidative Stress Enzyme, Silver Retention, Different Organs.

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