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Vidyasagar, G.
- Anti-Inflammatory and Wound Healing Activity of Melhania Futteyporensis Munro Ex Masters Leaf
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PDF Views:2
Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura, Post-Kakanpur, Tal.-Godhra, Panchmahal (District), Gujarat-389713, IN
1 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura, Post-Kakanpur, Tal.-Godhra, Panchmahal (District), Gujarat-389713, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 233-238Abstract
The methanolic and aqueous extract of Melhania futteyporensis leaves, at the doses of 200 and 400 mg/kg body weight, were tested for antiinflammatory and wound healing activity. The carrageenan induced rat paw edema model was selected to evaluate anti-inflammatory activity. The percentage inhibition of paw edema by the extracts was found to be significant at the dose of 400 mg/kg body weight, compared to control. The exhibited anti-inflammatory activity of Melhania futteyporensis was comparable with the standard drug aspirin. The wound healing activity was evaluated by using excision wound model of albino wistar rats. The percentage of wound contraction by both the methanolic and aqueous extracts was found to be significant at the dose of 400 mg/kg body weight. The exhibited wound healing activity was comparable with the standard drug povidone iodine ointment. The extract treated wounds were found to epithelize faster as compared to controls.Keywords
Melhania futteyporensis, Anti-Inflammatory Activity, Carrageenan Wound Healing Activity.
References
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- Hepatoprotective Activity of Bauhinia variegata Bark against Carbon Tetrachloride Induced Hepatotoxicity in Female Albino Wistar Rats
Abstract Views :227 |
PDF Views:4
Authors
Affiliations
1 Dept. of Pharmacognosy KLES College of Pharmacy, Belgaum, Karnataka, IN
2 Dept. of Pharmacognosy Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi), IN
3 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kutch-370460, Gujarat, IN
1 Dept. of Pharmacognosy KLES College of Pharmacy, Belgaum, Karnataka, IN
2 Dept. of Pharmacognosy Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi), IN
3 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kutch-370460, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 239-242Abstract
In recent times lot of interest has been generated to find out a natural remedy for hepatic disorders caused by toxins like alcohol and hepatitis virus. The present study is designed and investigate the hepatoprotective activity of Bauhinia variegata bark against carbon tetrachloride (CCl4) induced hepatotoxicity in female Albino Wistar rats. Forty two Albino Wistar female rats were divided in to seven equal groups each containing six animals. Four groups received the extracts of Bauhinia variegata bark and intraperitoneal (i.p.) CCl4 (2 ml/kg) with administration of extracts. One group was control, one treated with CCl4 and one with normal saline. The hepatotoxicity was assessing by plasma concentration of serum bilirubin and enzymes activities. The aqueous extract (500mg/kg b.w.) of Bauhinia variegata bark significantly reduced carbon tetrachloride induce damages in the liver which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. The attempt has been made to extract the active constituent and identified by phytochemical investigation and hepatoprotective activity of Bauhinia variegata bark.Keywords
Bauhinia variegataReferences
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