Research Journal of Pharmacology and Pharmacodynamics

Gauri Karwani ¹, Indrajeet Singhvi ¹, Santosh Gupta ¹

Affiliations
1 Pacific College of Pharmacy, Pacific Hills, Airpoart Road, Pratapnagar Extension, Udaipur, Rajasthan, 313001, IN

Abstract

Aims: To study the anti-secretory and anti-ulcer activity of Cartaeva nurvala(ethanolic extract) and its action against indomethacin plus pyloric ligation induced gastric ulcers in rats.

Settings and Design: Rats treated with two oral doses of indomethacin suspension as a standard dose, at an interval of fifteen hours, two hours after the second dose of indomethacin, Pyloric ligation was carried the rats were destroyed by over-dose of anesthetic ether. Pyloric ligation was done only to collect the gastric content for analysis.

Methods and Material: Indomethacin plus pyloric ligation (PL) induced gastric ulceration model was used in the study.

Statistical analysis used: The results were expressed as mean ± SEM. The significance of difference between mean values for the various treatments was tested using the unpaired student 't' test P<0.05 was considered statistically significant.

Results: Treatment from Cartaeva nurvala crude extract for fifteen days significantly reduced ulcer index when compared with control group. Crude extract also significantly reduced volume of gastric secretion, free acidity and total acidity. A significant increase in total carbohydrate (TC) and TC/total protein (TP) ratio of gastric juice was also observed. No significant change in the total protein was noted.

Conclusions: Cartaeva nurvala was found to be an effective anti-ulcerogenic agent, whose activity can well be compared with that of ranitidine hydrochloride.

Keywords

Anti-Ulcer Activity, Cartaeva nurvala, Indomethacin Plus PL.

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Gauri Karwani ¹, Siddhraj S. Sisodia ¹

Affiliations
1 Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, 313 001, IN

Abstract

Chenopodium album Linn. is a commonly used herbal drug against many diseases. The hepatoprotective activity of hydroalcoholic extract of dried powder of leaves plant of Chenopodium album Linn. was investigated in hepatotoxicity rat model. Hepatotoxicity was induced in Wistar rats by intraperitoneal injection of carbon tetrachloride. Different doses were tested to decide the dose related hepatoprotective efficacy of Chenopodium album Linn. (200 mg/kg, 400 mg/kg, 600 mg/kg body weight/day po for two weeks). The Hepatoprotective effect of these extracts was evaluated by liver function biochemical parameters (i. e. total bilirubin, total cholesterol, total protein, serum glutamateoxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase and In Vivo antioxidant enzyme superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidases (LPO) and catalase activities) and histopathological examination of liver. In extract-treated animals, the toxicity effect of carbon tetrachloride was controlled significantly by restoration of the levels of serum biochemical parameters as compared to the normal and standard drug silymarin treated groups. Histology of liver sections of the animals treated with the extracts showed the hepatic cell regeneration. Therefore, the results of present study support the hepatoprotective effect of Chenopodium album Linn.

Keywords

Chenopodium album Linn., Hepatotoxicity, Hepatoprotective, Carbon Tetrachloride.

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