Research Journal of Pharmacology and Pharmacodynamics

G. Dama ¹, J. Bidkar ¹, S. Deore ¹, M. Jori ¹, P. Joshi ¹

Affiliations
1 Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, IN

Abstract

The World Health Organization (WHO) estimates that many people harbour parasitic worm infections. The present study was carried out to evaluate the Helminthic activity of leaves of Michelia champaca using Pheretima posthuma as test worms. The various concentrations (30 mg/ml and 70 mg/ml) of both methanolic and aqueous extracts of leaves were used in study. The Albendazole (30 mg/ml and 70 mg/ml) and Ayurvedic preparation Vidangarishta (10%V/V) were used as standards. The distilled water was used as control. The study involved determination of Paralysis time (P) and Death time (D) of the earth worms. There was dose dependent anthelmintic activity shown by the extracts. The methanolic extract of both concentrations showed the less P and D time as compare to aqueous extract. The both extracts showed the greater P and D time than the standard. Also the Ayurvedic standard showed the greater P and D time than the Albendazole.

Keywords

WHO, Parasite, Michelia champaca, Pheretima posthuma.

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