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Rajasekhar, K. K.
- Local Anaesthetic Activity of Calotropis gigantea Latex in Frog and Guinea Pig
Abstract Views :236 |
PDF Views:2
Authors
K. K. Rajasekhar
1,
V. Shankarananth
1,
M. Rajagowtham
1,
B. Gowtham Kumar
1,
B. Thejnayan
1,
M. Pavankumar
1
Affiliations
1 Dept of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P., IN
1 Dept of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 178-180Abstract
This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution ) exhibited significant local anaesthetic activity.Keywords
Calotropis Gigantea, Milky Latex, Local Anaesthetic Activity, Nerve Block Method, Muscle Twitch Method and Infiltration Method.
References
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- Oudhia P and Tripathi RS. 1998. Proc. National Conference on Health Care and Development of Herbal Medicines, IGAU, Raipur, India 29-30,71-78.
- Oudhia P, Kolhe SS and Tripathi RS. 1997. Legume Res. 20(2),133-136.
- Ramanathan T. Evaluation of local anaesthetic activity from Calotropis procera linn in Euphlyctis hexadactylus. Plant Archives,2008,8,2,995.
- Rajasekhar KK, Shankarananth V, Venkateswarlu M, Nirosha M, Thushara bindhu D and Narender reddy K. Local anaesthetic activity of Tabernaemontana coronaria latex in frog and guinea pig. Journal of Pharmacy Research November 2009 , 2(11),1691-1693.
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- Zipf HF and Dittman EC.,General Pharmacological effects of local anaesthetics. In Local anaesthetics, Vol.1,International Encyclopedia of Pharmacology and therapeutics.Sect.8.(Lechat.P.,ed)Pergamon press,Ltd.,Oxford,1971,191-238.
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- Potentiation of Local Anesthetic Activity of Calotropis Gigantea Latex with Epinephrine and pH in Guinea Pig
Abstract Views :273 |
PDF Views:2
Authors
K. K. Rajasekhar
1,
V. Shankarananth
1,
C. Sreelakshmi
1,
A. Sushmitha
1,
S. Ch. Moulali
1,
V. Swetha Reddy
1
Affiliations
1 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., IN
1 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati- 517503, A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 197-199Abstract
The present work describes the potentiation of local anesthetic activity exhibited by milky latex obtained from Calotropis gigantea, with epinephrine and pH. The milky latex at a dilution of 1:10, exhibited significant local anesthetic activity. Both epinephrine (5μg/ml) and pH of 7.2 prolonged the duration of local anesthetic activity. The method used is infiltration anesthesia in Guinea pig. In conclusion, the duration of the effect produced by combination of Calotropis gigantea latex and epinephrine was longer than the combination of latex and pH as well as latex alone.Keywords
Calotropis Gigantea, Milky Latex, Epinephrine, pH and Infiltration Anesthesia.References
- Rastogi Ram P and Mehrotra BM. 1991 In : Compendium of Indian Medicinal Plants. Pbl. Central Drug Research Institute, Lucknow and Publications & Information Directorate, N. Delhi, 70-73.
- Oudhia P, Kolhe SS and Tripathi RS. 1998a. In: Abstract. III International Congress on Allelopathy in Ecological Agriculture and Forestry, UAS, Dharwad, India 18-21.
- Caius JF. 1986. The medicinal and poisonous plants of India. Scientific Publ, Jodhpur, India.
- Das BB. 1996. Rasraj Mahodadhi. Khemraj Shri Krishnadas Prakashan, Bombay.
- Agharkar SP. 1991. Medicinal plants of Bombay presidency. Scientific Publ, India. 48-49.
- Ghosh NC 1988. Comparative Materia Medica. Hannemann Publ. Co. Pvt. Ltd. Calcutta, India.
- Singh U, Wadhwani AM and Johri BM. 1996. Dictionary of Economic Plants of India. Indian Council of Agricultural Research, New Delhi. 38-39.
- Oudhia P and Tripathi RS. 1998. Proc. National Conference on Health Care and Development of Herbal Medicines, IGAU, Raipur, India 29-30,71-78.
- Oudhia P, Kolhe SS and Tripathi RS. 1997. Legume Res. 20(2),133-136.
- Herbal monograph, Himalaya herbal healthcare, India.
- Grieve M,A modern herbal.www.botanical.com.
- Ramanathan T, Evaluation of local anesthetic activity from Calotropis procera in Euphylyctus hexadactylus. Plant Archives,2008,8(2): 995-997.
- Rajasekhar KK, Shankarananth V, Venkateswarlu M, Nirosha M, Thushara bindhu D and Narender reddy K. Local anaesthetic activity of Tabernaemontana coronaria latex in frog and Guinea pig. Journal of Pharmacy Research November 2009 , 2(11),1691- 1693.
- Rajasekhar KK, Shankarananth V, Rajagowtham M, Gowtham kumar B, Thejnayan B and Pavankumar M. Local anaesthetic activity of Calotropis gigantea latex in frog and Guinea pig. Research Journal of Pharmacology and Pharmacodynamics, March-April 2010, 2(2), In Press.
- Rajendra Prasad Y, Rajasekhar KK, Shankarananth V, Tejaswi E, Prathyusha RJ, and Sunandhana T. Potentiation of Local anaesthetic activity of Calotropis procera latex with epinephrine and pH in Guinea pig. International Journal of Pharma Recent Research December 2009 , 1(1),54-58.
- Rajasekhar KK , Shankarananth V, Dinesh kumar P, Kartheek Y,Harinatha reddy P, and Mukesh O. Effect of epinephrine and pH on Local anaesthetic activity of Tabernaemontana coronaria latex in Guinea pig. Journal of Pharmacy Research December 2009, 2 (12), 1886-1888.
- Bernards CM and Kopacz DJ, Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans. Anesthesiology, 1999,91: 962-968.
- Hille B. Theories of Anesthesia, General perturbations versus specific receptors. Mechanisms of Anesthesia,Vol.2, Progress in Anesthesiology, Raven press: Newyork,1980, 551-565.
- Indian Pharmacopoeia, Ministry of Health and Family Welfare, Government of India, Controller of Publications, Delhi, Vol- II,1996,A-144.
- Kulkarni SK. Handbook of Experimental Pharmacology, Local anesthetics, 3rd edition, 1999, 152.
- Evaluation of Antiulcer Activity of Coccinia grandis Leaves
Abstract Views :250 |
PDF Views:0
Authors
C. Girish
1,
S. Vineela
2,
Y. Narasimha Reddy
3,
O. V. S. Reddy
4,
K. K. Rajasekhar
5,
V. Shankarananth
5
Affiliations
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, IN
2 MAM College of Pharmacy, Narsaraopet, Guntur, IN
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, IN
4 Dept of Biochemistry S.V. University, Tirupati.517-501, IN
5 Sri Padmavathi School of Pharmacy, Tirupati, IN
1 Division of Pharmacy, Dept of Biochemistry, S.V. University, Tirupati.–517-501, IN
2 MAM College of Pharmacy, Narsaraopet, Guntur, IN
3 University College of Pharmaceutical Sciences, Kakatiya University, Warangal, IN
4 Dept of Biochemistry S.V. University, Tirupati.517-501, IN
5 Sri Padmavathi School of Pharmacy, Tirupati, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 92-95Abstract
The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (250 mg/kg&500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential antiulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.Keywords
Coccinia grandis, Pylorus Ligation, Ethanol Induced Ulcer Model, Ulcer Index, Omeprazole.References
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