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Prasad, K.
- Influence of Coenzyme Q10 on Phenothiazine Induced Extrapyramidal Symptoms in Rats
Authors
1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 248-251Abstract
Single dose and multiple dose influence of, Coenzyme Q10 in chlorpromazine induced catatonia was studied in adults albino rats of either sex. The study intended to find the role of antioxidants coenzyme Q10 in controlling extrapyramidal side effects. Phenothiazine derivatives produce catatonia as an unwanted side effect when used especially for prolonged periods of time in psychiatric disorders. The catatonia was induced in albino rats using chlorpromazine in the dose of 0.9mg/200g p.o. and the degree of catatonia was recorded.
Coenzyme Q10 was administered first followed by chlorpromazine after 30 minutes p.o in single dose studies. In multiple dose studies Coenzyme Q10 was administered for 8 days followed by the combination of Coenzyme Q10 and chlorpromazine on 9th day as described above and the degree of catatonia was scored. The study reveals that coenzyme Q10 produced statistically significant reduction of extrapyramidal symptoms in both single and multiple dose studies. Thus coenzyme Q10 has beneficial effects in controlling the toxicity symptoms of phenothiazines. Since, coenzyme Q10 is used safely in the form of food supplement it can be recommended in patients who are using phenothiazine derivatives for prolonged periods of time.
Keywords
Chlorpromazine, Catatonia, Coenzyme Q10, Extrapyramidal Symptoms.References
- Rang HP, Dale MM, Ritter JM, Moore PK. Antipsychotic drugs. Pharmacology, Churchill Livingstone Robert Stevenson House Edinburgh EH 1 3AF. 1999; 547-548.
- Tripathi KD. Drugs used in mental illness: Antipsychotics and antianxity drugs. Essentials of Medical Pharmacology, Jaypee Brothers medical publishers (P) LTD, New Delhi 2008; 6th pp.423-433.
- Reddick B, Stern TA. Catatonia, neuroleptic malignant syndrome,and serotonin syndrome. In:Stern TA, Herman JB, eds. Massachusetts General Hospital Psychiatry Update & Board Preparation, New York, NY: McGraw 217-224.
- Hawkins JM, Archer KJ, Strakowski SM, et al. Somatic treatment of catatonia. Int J Psychiatry Med 1995; 25:345.
- Fink M, Taylor MA. The many varieties of catatonia. Eur Arch Psychiatry Clin Neurosci 2001; 251(Suppl. 1):8-13.
- Satyanarayan U, Chakrapani U. Free radicals and antioxidants. Essentials of Biochemistry, Books and Allied (P) Ltd. Kolkata 700010, 2nd Ed:pp. 351-354.
- Hasan MY, Alshuaib WB, Singh S, Fahim ascorbic acid on lead induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle". Life Sci. 2003; 73 (8): 1017-25.
- Huang J, Agus DB, Winfree CJ et al. " blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke the National Academy of Sciences 2001; 98 (20): 11720-4.
- Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271: 195-204, 1995.
- Berbel-Garcia, A. et al. "Coenzyme Q 10 improves lactic acidosis, stroke like episodes, and epilepsy in a patient with melas". Clinical Neuropharmacology 2004; 27:187-191.
- Damian MS. et al. "Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest". Heart Foundation 110: 3011-3016.
- Folkers K. Basic chemical research on Coenzyme Q10 and integrated clinical research on therapy of diseases. In Lenaz G, ed. Coenzyme Q. New York : John Wiley and sons, 1985.
- Kishi T, Makino K, Okamoto T, et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q. In: International of Symposium on Coenzyme Q. Biomedical and clinical aspects of Coenzyme Q. New York, NY: Elsevier Science Publishing Co; 1980(2): 139-157.
- Satoh K, Sakagami H. Effect of metal ions on radical inte and cytotoxic activity of ascorbate. Anticancer Res 1997; 17:1125-1129.
- Eipper BA, et al. "Peptidylglycine apha monooxygenase: a multifunctional pr processing,and routing domains". Protein Sci. 1993; 2 (4): 489-97.
- Englard S, Seifter S. "The biochemical functions of ascorbic acid". Annu. Rev. Nutr. 1986; 6: 365-406.
- Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats
Authors
1 Shri Vishnu College of Pharmacy, Bhimavaram-534202, A.P., IN
2 HKES College of Pharmacy, Department of Pharmacology, Sedam Road, Gulbarga-585105, Karnataka, IN
3 HKES College of Pharmacy, Department of Pharmacology, Gulbarga-585105, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 202-206Abstract
Peptic ulcer is a chronic and appalling disease. Today, it is dominant among the diseases that affect the world's population. The principal factors causing this disease are inadequate dietetic habits, prolonged use of non-steroidal anti-inflammatory drugs, stress and infection by Helicobacter pylori, in addition to other factors of genetic origin. The present study was designed to evaluate the combination effect of vitamin E with lansoprazole against pylorus ligation induced ulcer model in rats. The antiulcer effect of the combination of vitamin E 0.9mg/200g and lansoprazole 0.54mg/200g b.w. orally was compared with the reference standard lansoprazole 0.54mg/200 g b.w. orally. The ulcer index and other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice were estimated. The ulcer index and other biochemical parameters like volume (***P < 0.001), free acidity (***P < 0.001), total acidity (***P < 0.001) and pH (**P < 0.01), of gastric juice showed reduction when compared to standard lansoprazole. The percentage protection of combination was 92.9% as compared to standard lansoprazole 82.8%. Thus the combination group was found to be synergistic in nature when compared to lansoprazole alone.Keywords
Antiulcer Activity, Vitamin E, Lansoprazole, Pylorus Ligation Model, Ulcer Index.References
- Falca H.S., Mariath I.R.,. Diniz M.F.F.M, Batista L.M., Barbosa-Filho J.M., Plants of the American continent with antiulcer activity. Phytomedicine 2008: 15; 132-146.
- Rao, C.V., Sairam, K., Goel, R.K.. Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Indian J. Physiol. Pharmacol 2000: 44, 335-441.
- Diplock AT, Machlin LJ, Packer L, Pryor WA. Vitamin E: Biochemistry and health implications. Ann NY Acad Sci 1989; 570: 555-590.
- Alfred Goodman Gilman, Joel G.Hardman, Lee E. Limbird. The Pharmacological basis of therapeutics 11th edition 2006:1005-06.
- Tripathi KD. Essentials of medical pharmacology 6th edition, New Delhi Jaypee Brothers, Medical Publishers; 2007: 633.
- Laurence DR, Bacharach AL. Evaluation of drug activities and pharmacometrics. London and New York. Academic press; 1:160-61.
- Shay M, Komarov SA, Fels D, Meranze D, Gruenstein H and Siplet. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945;5:43-61.
- Kulkarni SK. Handbook of Experimental Pharmacology, 3rd Ed. New Delhi: Vallabh Prakashan; 2005.
- Fathihah B, Mahmood AA, Sidik K and Salmah I. The antiulcer and cytoprotective effect of ageratum conyzoides-honey combination in rats, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, JUMMEC 2003-2005; 8: 28-32.
- Deshpande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia purpurea in rat. Indian J Pharmacol 2003; 35:168-72.
- Kelly Samara de Lira mora, Guilherme Eduardo Nunes Dias,Meri Emili Ferreira Pinto,Anderson Luiz Ferreira,Alba Regina Monteiro Souza Brito,Clelia Akiko Hiruma Lima and et.al. Flavonoids with gastroprotective activity, Molecules. 2009;14:979-1012.
- Tasman-Jones C. Pathogenesis of peptic ulcer disease and gastritis: Importance of aggressive and cytoprotective factors. ScandJ Gastroenteml. 1986; 122:1-5.
- Aly A. Prostaglandins in clinical treatment of gastroduodenal mucosal lesions: A review. Scand J Gastroenterol. 22(S137); 1987:43-9.
- Goel RK and Bhattacharya SJL. Gastroduodenal mucosal defense and mucosal protective agents. Indian J Exp Bio 1991;29:701-14.
- George S, Sathiamoorthy A, Sathiamoorthy SS. Effect of alpha tocopherol on gastric ulcers induced by pylorus ligation in rats. Indian J pharmacol 1999; 31: 431-3.
- Glossary of Callistemon lanceolatus D.C. – An Ornamental Plant with Marvellous Properties
Authors
1 Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shivamogga (Dist)-577201, Karnataka, IN