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Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 7, No 2 (2015), Pagination: 61-67
Abstract
Alzheimer is an irreversible, progressive brain disorder related to changes in nerve cells that result in the death of brain cells. The present work is focused on generating scientific data on the nootropic activity of Sumenta, in Alzheimer's induced experimental animals like mice and rats. The objective of the proposed study was to investigate the therapeutic potential of poly herbal formulation Sumenta on Alzheimer's in different animal models. Like Locomotors activity, Hebb's- William maze. Evaluation of nootropic activity was done by using 3 doses of PHFS (250, 500 and 750 mg/kg) in vivo models. Locomotors function test, Hebb's- William maze Hebb's William maze was used for studying learning, memory and reasoning in animals. The clever the rat, the more quickly it is able to make use of past experience and therefore more quickly it learns its way out in the maze. In the present study, we evaluated the effects of SUMENTA on learning, memory and reasoning model using the Hebb's William maze in mice. Drug treated animal group in Hebb's William maze showed transfer latency decrease compared to control. PHFS did not shown any significant changes in locomotors function, its suggested that it has no sedative action. The present study on nootropic activity with PHFS has shown significant nootropic Activity in different animal models.
Keywords
Polyherbal Formulation, Locomotion Activity, Hebb's- William Maze, TL.
